Forum Topic: new topic: Premade mRNA

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new topic: Premade mRNA

Messenger RNA (mRNA) is a single-stranded RNA molecule that is complementary to one of the DNA strands of a gene. The mRNA is an RNA version of the gene that transfers the information from the cell nucleus to the cell machinery that makes proteins. During decades of intense research in molecular biology and biochemistry, mRNA has gained great interest as a therapeutic agent. mRNA synthesized by in vitro transcription (IVT) methods, can be sequence optimized to improve translatability into proteins, as well as chemically modified to reduce immunogenicity and increase chemical stability using naturally occurring uridine modifications. In addition, synthetic mRNA also has some other advantages, e.g., the lack of risk for genomic integration, or the expression of the encoded protein in the cytoplasm without the need to cross the nuclear membrane. All these features make IVT mRNA a powerful alternative gene expression system for various applications including regenerative medicine, vaccination, the treatment of hereditary diseases and tumors, and cell engineering. [url][/url]

This topic was started by Mia Chou.

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