Forum Topic: CpG ODNs

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CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules containing unmethylated CpG motifs derived from bacterial DNA. CpG ODNs can directly stimulate B-lymphocytes, dendritic, and NK cells, resulting in an increase in innate immunity and antibody-dependant cell cytotoxicity (ADCC). Furthermore, it also can indirectly modulate T-cell responses, through the release of cytokines (IL-12 and IFN gamma), to induce a preferential shift to the Th1 (helper) phenotype resulting in enhanced CD8+ cellular cytotoxicity. Preclinical and clinical trials indicate that CpG ODNs can boost the immunogenicity of vaccines targeting infectious diseases and cancer, including acting as vaccine adjuvants to improve antigen-presenting cell function and promoting the induction of an antigen-specific adaptive immune response, preventing allergy by encouraging the development of T helper 1 (TH1)-type immune responses and so on. The characteristics of CpG ODN makes it is possible to better serve the research of vaccine and the immunotherapy of cancer. [url][/url]

This topic was started by Mia Chou.

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