Forum Topic: High-Content Biology and Screening

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High-Content Biology and Screening

High-content screening is a powerful cellular-biology method for peptide drugs discovery. In HCS, fluorescence imaging is commonly used, limited to a few fluorophores at a time. Meanwhile, HCS technology combines automated imaging and data analysis; thus, scientists carry out HCS assays for rapid screening of peptide compounds. Peptides were simultaneously screened based on the transfection efficiency, cytotoxicity, induction of cell permeability, and the transfection capacity toward non-dividing cells. It has been demonstrated that HCS is a valuable extension of the existing screening methods for in vitro evaluation of peptide molecules. HCS includes the added value that allows multiple parameters to be screened in parallel, thereby maximizing the useful information from a single screening event, which accelerates novel peptide drug development. [url][/url]

This topic was started by Caroline Miller.

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