Forum Topic: hERG Safety Assay

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hERG Safety Assay

ICH S7B guideline1 regulates in vitro IKr assay (such as hERG safety assay) and in vitro QT assay for identifying and assessing the potential of a test compound to delay ventricular repolarization. Ventricular repolarization is a complex physiological process determined by the duration of the cardiac action potential. It is the net result of the activities of many highly interdependent membrane ion channels and transporters. Many compounds can affect the activities of the ion channels or transporters, thus have the potential of delaying the ventricular repolarization and leading to prolonged QT interval. https://www.creative-bioarray.com/Services/hERG-Safety.htm

This topic was started by Bennie George.
Posted by chelsea clark on 2019-02-13 01:55:30
 
C57BL/6 Mouse Primary Dermal Fibroblasts from Creative Bioarray are isolated from tissue of pathogen-free laboratory mice. Mouse Primary Dermal Fibroblasts are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in Creative Bioarray Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and is delivered frozen.

https://www.creative-bioarray.com/C57BL-6-Mouse-Primary-Dermal-Fibroblasts-CSC-C4270X-item-2545.htm
Posted by chelsea clark on 2019-02-13 01:57:14
 
GROa is a member of the a (CXC) family of chemokines. It is produced by monocytes, neutrophils, mast cells, epithelial cells, endothelial cells, keratinocytes and tumor cells. GRO expression is inducible by serum or PDGF and/or by a variety of inflammatory mediators, such as IL-1 and TNF. GROa is a chemoattractant for neutrophils, lymphocytes, monocytes, and epidermal melanocytes. In addition, GROa induces activation of neutrophils and basophils, has angiogenic effects, inhibits erythrocyte invasion and decreases the expression of interstitial collagen.

https://www.creative-bioarray.com/products/cytokines-growth-factors-list-17.htm

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