Forum Topic: CiPA Cardiac Channel Assays

View topics list | Add post

CiPA Cardiac Channel Assays

Many withdrawn drugs have been shown to block the hERG channel, delaying repolarization of the cardiac action potential and leading to prolongation of the QT interval on an electrocardiogram. This can potentially initiate the arrhythmia known as Torsades de Pointes (TdP) with fatal consequences. While hERG is an important factor for cardiac liability, it is not the only factor. Excitation and relaxation of cardiac muscle is regulated by a variety of different ion channels.

This topic was started by Hannah Cole.

No user comments.

View topics list | Add post