Forum Topic: Nav1.5

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Nav1.5

Nav1.5 (SCN5A) is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Nav1.5 is found primarily in cardiac muscle, where it mediates the fast influx of Na+ ions (INa) across the cell membrane, resulting in the fast depolarization phase of the cardiac action potential. As such, it plays a major role in impulse propagation through the heart. Hundreds of genetic variants have been found in patients with a long list of cardiac manifestations. Mutations in NaV1.5 induce a vast number of cardiac diseases: https://acroscell.creative-bioarray.com/nav1-5.html

This topic was started by Hannah Cole.
Posted by on 2020-11-28 03:23:48
 
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