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Started by:
yang tulo

 
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BOC Sciences has directed sincere efforts toward providing customers with high quality small-molecule inhibitors (inhibitors, agonists and modulators) with optimal prices. Most of our products can be supplied ranging from milligrams to kilograms scale and arrived with analytic report.
https://www.bocsci.com/inhibitor-list-84.html
Since the PNA was proposed, chemical modification of its structural units has become one of the research focuses. In the modification of PNA structural unit, backbone modification is the main measure to improve the transport performance of PNA cells. The backbone modification refers to the modification of the N-(2-aminoethyl) glycine unit structure of the PNA. The backbone modification PNA has achieved certain success in increasing the water solubility and enhancing the hybridization performance. Moreover, partial backbone modified PNAs also have special advantages such as optical properties and self-assembly, which expand the application range of PNAs.

https://pna.creative-peptides.com/services/pna-backbone-modification.html
PROTAC (protein degradation targeted chimera) is a special protein degradation technology, which uses ubiquitin proteasome pathway, a natural protein degradation pathway in cells, to remove specific proteins that need to be degraded. A PROTAC molecule consists of two key domains: the domain that specifically binds to the target protein that needs to be degraded, and the domain that binds to the E3 ubiquitination ligase, which is linked by a specific linker. Unlike traditional small molecule inhibitors, which can only regulate the activity of target proteins, PROTAC can directly degrade target proteins through the protein destruction mechanism of cells themselves. Intracellular proteins with abnormal structure or function are labeled with polyubiquitin by a series of enzymes, which are then transferred to the proteasome for degradation.

https://ptc.bocsci.com/services/protac-design-services.html
Phenotypic screening technology is widely used as an indispensable drug discovery strategy. Phenotypic screening, which is also called 'classical pharmacology' or 'phenotypic drug discovery, is a method to screen out compounds that can change the phenotype on cell or animal disease models, and then in-depth explore the interaction of compounds against the target and the mechanism of the pharmacological effects the compounds.

https://www.pepdd.com/services/phenotypic-screening.html
The bases in PNA are generally bound to the backbone through acetyl groups. Changing the connection method and position of the base and the backbone will cause certain changes in the structure of the PNA, which may affect the stability of hybridization.

Now, because the modification of PNA is expected to solve the difficulties in its development and utilization in many fields, it is necessary to pay attention to the development and design of PNA. Creative Peptides is committed to providing tailor-made PNA research according to the needs of specific products.

https://pna.creative-peptides.com/services/modification-of-connection-between-nucleobase-and-backbone.html
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Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. The field of bioconjugation has had a considerable impact on academic research, clinical diagnostics and the production of therapeutics.

Peptides are an important type of molecules for derivatization by bioconjugation. Peptide–drug conjugates hold a promising stance in the
delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Both linear and cyclic peptides
have been explored as trafficking moiety due to ease of synthesis, structural simplicity, and low probability of undesirable immunogenicity.

https://www.creative-peptides.com/services/peptide-drug-bioconjugations.html
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The BIO International Convention attracts 15,000+ biotechnology and pharma leaders who come together for one week of intensive networking to discover new opportunities and promising partnerships. BOC Sciences brings together a wide spectrum of microbial fermentation services, including fermentation for special small molecules, fermentation process development, validation, and optimization, GRAS Services and CDMO Services.
https://www.bocsci.com/
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für mehr Besuch https://www.bestesparer.de/anker-rabattcode
As one of the widely-used molecular library screening approaches, medium and high throughput screening (M-HTS) have been utilized with the application of robotics and automation. The screening is an experimental process in which 103-106 peptide molecule compounds with known structures are screened in parallel. Scientists therefore use M-HTS to quickly test thousands of samples with biological activities at the model organism, cell, pathway, or molecular levels. Large compound libraries can be screened in a cost-effective way which helps to accelerate target analysis.

https://www.pepdd.com/services/medium-and-high-throughput-screening.html
Peptides are ideally suited to mimic natural ligands and usually act in an antagonistic or agonistic manner. Small active peptide molecules have huge potential to be developed as vaccines, diagnostic reagentsand lead compounds. Therefore, peptides have become the highlight of drug discovery, especially due to their small size, structural diversity and high specificity for a given target. Moreover, peptides can be selected from large natural or artificial peptide libraries rapidly, and are easy for chemical processing and synthesis.

https://www.pepdd.com/services/peptide-drug-screening.html
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The modification of PNA includes two types of modification of backbone and base. Modification is a process of optimizing structure and performance, focusing on safety and effectiveness. Creative Peptides has a full range of services and expertise to help customers successfully start and complete the PNA development plan that meets the required functions.

https://pna.creative-peptides.com/services/pna-modification.html
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As a leading CRO serving pharmaceutical and biotech companies worldwide, BOC Sciences established a PROTAC® development platform utilizing years of endeavor in chemical synthesis and analysis. We provide a wide range of services to support the pharmaceutical industry through all stages of PROTAC drug discovery including ligand design and synthesis for the target protein and E3 ligase, PROTAC design services, linker design, and optimization Services, etc. We specialize in the development and GMP manufacture of pharmaceutical grade products. Our capacity to provide pharmaceutical discovery services across the entire spectrum of the PROTAC drug discovery process has assisted many of our esteemed clients in reaching their R&D goals.

https://ptc.bocsci.com/services/protac-gmp-services.html
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In order to simplify and accelerate the discovery of PROTAC, it is necessary to grasp the design rules of PROTAC, which is helpful to establish a reliable PROTAC evaluation platform. To date, most reported PROTAC designs are based on target protein-binding ligands (usually inhibitors). Because the crystal complex structure of the target protein and its binding ligand and the structure-activity relationship information of the ligand have been used to guide PROTAC design, such as determining the Linker binding site of the target protein binding ligand. Recent research uses bioinformatics to guide PROTAC optimization. Bioinformatics methods play an irreplaceable role in the process of drug discovery, especially for the analysis of large-scale multi-group data. at present, many disease-related database resources have emerged, and a variety of bioinformatics methods have been established to discover potential drug targets based on biological network characteristics, multi-gene chip, proteome, metabolome data and so on. The target drug availability and drug side effects were predicted.

https://ptc.bocsci.com/services/protac-design-based-on-bioinformatics.html
The linker is responsible for linking two key domains of PROTAC: the domain that specifically binds to the target protein that needs to be degraded, and the domain that binds to the E3 ubiquitin ligase. To date, several types of connectors have been reported and used in the formation of PROTAC ternary complexes, such as PEG liner, alkyl liner and "click chemical" liner. It plays an important role in the effective ubiquitination and final degradation of target proteins.

https://ptc.bocsci.com/services/linker-design-and-optimization-services.html
Carbohydtrates are one of four major classes of biomolecules in living organisms, playing an important role in nutrition supply, energy transportation, cell composition, etc. Carbohydtrates exist naturally in multiple foods. It is a compound made up of carbon (C) hydrogen (H) and oxygen (O) atoms. Carbohydrates are classified as simple or complex accoding to their structures. Simple carbohydrates include monosaccharides and disaccharides, of which most natural sugars are disaccharides. Complex carbohydrates include oligosaccharides and polysaccharides, such as Fructooligosaccharides (FOS), starch and cellulose.
https://www.bocsci.com/carbohydrates-list-1999.html

Dear All,

I would like to work on phenotyping tomato and brinjal (egg plant) for abiotic stress tolerance traits. For that I would like to know what are the materials and methods needed.

Why I am asking is that if any one in the community had developed a set of protocols for low cost phenotyoing, i would like to use it.

Please connect me with people who are working on phenotyping tomato.

Thanks
Sridhar
Neoantigens are a class of peptides that are bound by HLA and are produced by tumor-specific mutations. They are highly immunogenic because they do not exist in normal tissues and can be used as biomarkers to distinguish cancer cells from normal cells.

The use of tumor-specific neoantigen peptides has become a rapidly growing and very promising therapeutic field in the synthesis of cancer vaccines. In terms of adapting to patient specifications and timely delivery of care, the preparation of neoantigen peptides requires the highest level of care and reliability.

With our thorough expertise and experience in the field of peptide chemistry, cGMP certified manufacturing facilities, and neoantigen peptide synthesis technology, we can produce non-GMP grade and GMP grade peptides from milligram quantities to commercial requirements of multi-kilograms or more. The advantage of manufacturing active peptides at a low-cost makes Creative Peptides stand out among international manufacturers.

https://www.creative-peptides.com/services/neoantigen-peptides-vaccine-service.html
Peptide drug refers to a peptide having a specific therapeutic effect extracted by chemical synthesis, genetic recombination or animal or plant, and is a specific application of the peptide in the field of medicine. The biological activity of the peptide is extensive and important, and it can be widely applied to the endocrine system, the immune system, the digestive system, the cardiovascular system, the blood system, the musculoskeletal system, etc.

As a medicine, peptide has many advantages such as strong physiological activity, low immunogenicity and high curative effect. With the continuous development of biotechnology, its status in the treatment of human diseases has become increasingly important, and it has become an international pharmaceutical industry. In recent years, the annual growth rate of the peptide drug market has reached 20%, far exceeding the annual growth rate of 9% in the overall pharmaceutical market, which has brought huge profits to pharmaceutical companies.

https://www.creative-peptides.com/services/peptide-drug-discovery.html
Creative Peptides Design PlatformTM (CPDP) has developed peptide information compression technology, which uses bioinformatics methods to compress peptide information, which can integrate the information of multiple peptide into one peptide, so as to contain a large amount of peptide information in a relatively small storage volume. It opens up a new way to research and develop peptide drugs. Based on this technology, we have constructed a total peptide library, containing nearly 500 million different peptide sequence information in a library of approximately 80,000 peptides, which will increase the screening efficiency by approximately 6,000 times.
https://www.creative-peptides.com/services/total-peptide-library-construction-technology.html
Phage display technology is a powerful tool that can be used to select binding partners from a complex library, which takes advantage of the direct connection between phage-displayed peptides and the nucleic acid encoding them. The goal of it is to separate the peptides with high affinity and specificity for the target by conducting repeated affinity selection. This method has been widely applied to rapidly screen of new drugs or lead compounds such as biologically active peptides, proteins and receptors.

https://www.pepdd.com/services/phage-display.html
The replacement of the backbone C has the advantage of not changing the configuration of the PNA, and generally does not reduce the hybridization performance of the PNA.

Creative Peptides provides high-quality PNA backbone modification services to promote the PNA development of our customers, we are committed to advancing and accelerating your research plan.

https://pna.creative-peptides.com/services/modification-by-c-replacement.html
Fluorescent techniques have revolutionized biochemical research over the last 20 years. Because they have characteristics of high sensitivity, selectivity, fast response time, flexibility and experimental simplicity, the use of fluorescent techniques in biological research is very widespread. In many cases, biological sensors consist of fluorescent versions of a particular protein.
https://www.creative-peptides.com/services/fluorescence-and-dye-labeling-peptides.html
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I am a college student engaged in plant breeding. I want to study the genome-wide analysis of cassava disease-related gene families. Any suggestions?
The backbone of PNA is N-(aminoethyl) glycine. At present, many studies have introduced chiral branches at α, β, and γ to improve its shortcomings and make PNA better in the fields of biology, biotechnology, medicine, etc.

Creative Peptides provides comprehensive PNA modification services, including the introduction of chiral branched chains with different functions at different sites to meet customer requirements for PNA monomer functions.

https://pna.creative-peptides.com/services/modification-by-introducing-chiral-branches.html
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High-content screening is a powerful cellular-biology method for peptide drugs discovery. In HCS, fluorescence imaging is commonly used, limited to a few fluorophores at a time. Meanwhile, HCS technology combines automated imaging and data analysis; thus, scientists carry out HCS assays for rapid screening of peptide compounds. Peptides were simultaneously screened based on the transfection efficiency, cytotoxicity, induction of cell permeability, and the transfection capacity toward non-dividing cells. It has been demonstrated that HCS is a valuable extension of the existing screening methods for in vitro evaluation of peptide molecules. HCS includes the added value that allows multiple parameters to be screened in parallel, thereby maximizing the useful information from a single screening event, which accelerates novel peptide drug development.
https://www.pepdd.com/services/high-content-biology-and-screening.html
Diastereomers are stereoisomers in which molecules have two or more chiral centers and the relationship between molecules is not mirrored. In PROTAC drug development, in order to evaluate the pharmacokinetics of a single diastereomer or mixture of diastereomers, manufacturers should quantitatively analyze samples from the early stages of drug development for a single diastereomer in vivo. This will allow the assessment of the possibility of mutual transformation as well as the distribution of absorption, distribution, biotransformation and excretion (ADBE) of individual isomers. When the drug is a raceme and the pharmacokinetic characteristics of the isomers are different, the manufacturer should monitor the diastereomer separately to determine properties such as dose linearity and the effects of metabolic or excretory changes and drug-drug interactions.

https://ptc.bocsci.com/services/protac-diastereomer-design-negative-control.html
Carbohydtrates are one of four major classes of biomolecules in living organisms, playing an important role in nutrition supply, energy transportation, cell composition, etc. Carbohydtrates exist naturally in multiple foods. It is a compound made up of carbon (C) hydrogen (H) and oxygen (O) atoms. Carbohydrates are classified as simple or complex accoding to their structures. Simple carbohydrates include monosaccharides and disaccharides, of which most natural sugars are disaccharides. Complex carbohydrates include oligosaccharides and polysaccharides, such as Fructooligosaccharides (FOS), starch and cellulose.

https://www.bocsci.com/carbohydrates-list-1999.html
Peptide lead optimization is to improve upon a lead molecule that demonstrates activity at a target of interest by optimizing its potency or selectivity at the target and its absorption, distribution, metabolism and elimination (ADME) properties. For a successful peptide lead optimization, access to a reliable in vitro assay system is of utmost importance. This allows for precise SAR evaluations based on the binding affinity of peptide analogs to the target protein.

In order to make a compound a drug sample, at least five basic attributes need to be considered including potency, bioavailability, duration, safety, and pharmaceutical acceptability.

https://www.creative-peptides.com/services/peptide-lead-optimization.html
Started by:
Isaak Tecle
2022-05-17 05:00:24
 
Started by:
Amir Tavassoli
2022-05-14 09:05:08
 
Dear Sir/Madam
Hi
I need all of tomato reference and integrated maps such as "Integrated map: Yellow Stuffer X LA1589 and Sun1642 X LA1589".
But when I choose the map, I see "Server error" message.
Please let me know how can I get these maps.
Regards.
2022-05-10 10:07:44
 
Hi dears,
Is there any possibility that someone can share the cDNA library of benthamiana? Please let me know, if it is possible. Thanks.
Started by:
optimus optimus
2022-04-30 15:32:03
 
Hi,
I am very confused browsing literature because I can not find a clear statement about the ploidy of N. benthamiana.
N. tabacum is clearly an allotetraploid, and tetraploid (2n = 4x = 48), with 4 copies of n=12. Genome size over 4.5 Gb, however,
N benthamiana it is reported to be an "ancient" allotetraploid, but currently it is n=19, and 38 total number of chromosomes, so it seems that from the ancient allotetraploid (48 chromosomes), genome fractionation has occurred and 38 remains, and that currently the genome is "diploid" (2n = 2x = 38). Is this correct?. Is N benthamiana diploid?.
Thank you very much.
Best regards,
The plant biotechnology and molecular breeding laboratory at Mid-Florida Research & Education Center at the University of Florida is seeking a highly motivated scientist to conduct studies of the environmental effect on tomato seed development, which is sponsored by FFAR for three years. The objective of this project is to identify the small RNAs that regulate seed development in response to maternal temperatures. This position requires a person with horticultural practices in growing tomato plants and a strong background in small RNA sequencing and analysis. The majority of research activities will be completed at Mid-Florida Education and Research Center, which is about 15miles from Orlando downtown, Florida; occasional travel to other states such as California may be required.

Applicants should receive a Ph.D. degree within the past 5 years with a solid background in bioinformatics and molecular biology/plant biotechnology, and have at least one first-authored publication in a peer-reviewed journal. Expertise in plant molecular techniques (small RNA delivery, siRNAs manipulation, CRISPR gene-editing) and research experiences in tomato or seed biology will be highly preferred. Candidates should have excellent skills in communications in oral and written English, skills in critical thinking, and are able to work independently in a culture-diverse environment. Applicants with legal visa status in the U.S. will be seriously considered. Salary is competitive and commensurate with background and experience($48000 plus medical benefit etc.). This position will be immediately available and remain open until filled. The term for this position is one year, and renewable contingent on academic performance for at least another 2 years. Qualified applicants should send a CV, and contact information for 3-4 references by email to hhuo@ufl.edu.
I would like to know whether Triticum aestivum database is updated and is there any reference where I researchers have designed construct for VIGS in wheat
Started by:
Erwin Aragon
2022-04-27 09:59:10
 
Dears friends: I want to Know if Are there microsatellite or other molecular marker that can be used for identify differents species in tomato??? i mean between sculentum and
Started by:
Lukas Mueller
2022-04-19 01:49:27
 
In the next few years, hundreds of Solanaceae will be sequenced using next generation sequencing methods. If you intend to sequence a Solanaceae, please provide information on the species to avoid duplicate sequencing of accessions on the SGN SOL-100 page http://solgenomics.net/organism/sol100/view. This topic is for the discussion of SOL-100 related questions.
Started by:
Naama Menda
2022-04-18 13:53:25
 
This topic discusses issues in developing controlled-vocabularies for describing Solanaceae phenotypes and traits.
Most should be covered by the 'Solanaceae Phenotype Ontology' (SPO)
(see SGN->Tools->Ontology browser) which is growing by demand of its users community.
Terms which exist in other ontologies (PO, PATO, etc) are mapped to SPO terms.
In some cases it will be advised to use other vocabularies, instead of providing new SPO terms.
Started by:
Eva Huala
2022-04-18 08:45:57
 
Hello
I would like to access the potato annotation file in iTAG nomenclature with their respective TAIR nomenclature codes equivalent to each gene. Is that possible? I can not find the annotation file that includes that information. I need to match the nomenclature accepted in DAVID (The Database for Annotation).

Example in PGSC annotation available in Phytozome

PGSC0003DMG400000001 = AT1G12600.1
Is it safe to directly map the gene identifiers (Solyc00g005000.2) using the primary id (Solyc00g005000)?
Started by:
john binns
2022-04-06 00:08:28
 
This topic is for members of the SOL community from around the world to publish job openings. If interested, please reply directly to the poster. Job postings submitters please note that the postings will be removed by default 8 months after posting.
Dear all,
I need your help here. Does anyone know how to convert ITAG gene tomato annotations to KEGG (or UniProt) ID?

Thanks in advance!

Irene
Started by:
Lukas Mueller
2022-04-03 02:58:15
 
This topic contains release notes for new SGN website features.
Started by:
Peng Wang
2022-03-17 15:18:58
 
Here we report a serious problem with tobacco gene models. We tried to map the gene models of Nitociana tabacum (TN90), which you provide in your ftp, to the TN90 genome assembly sequences. Unfortunately, a lot of gene models could not be mapped. Of the 122388 gene models you provided in the gene model file,only 53714 could be mapped to the genome assembly. We do not know what method you used to identify gene models. Could you check all the datasets of the three tobacco varieties(TN90, K326 and Bathma)? Thank you.
Started by:
Lukas Mueller
2022-03-12 04:11:21
 
This topic contains release notes for new SGN data releases.
Hi, I would like to know if there is a straightforward way to translate the one nomenclature to the other.
Both refer to genes/loci/protein, right... but if I have to compare to see coincidences from one list in one format and one list in the other (having hundreds of proteins/genes in each list), I can die doing searches and endless alignments, and still not accomplishing the job...
Please help.
Thank you very much.
Started by:
César Benavidez
2021-12-26 15:42:25
 
Dear friends, I am about to begin an investigation of lycopene content in tomato species, as well as identification of microsatellites to identify the gene or genes responsible for the character under study, so I ask if I could help with information on the research topic . Thank you very much
Started by:
Emilio Ortiz
2014-01-19 23:11:32
 
Hi,

Is there any way to download the 2860 COSII sequences? Please let me know.


Thank you,
This topics is for the researchers of the SOL community around the world who need some specific materials for their experiments and express some request to those who could provide them with the expected materials or resources.
Started by:
Douglas Maxwell
2008-07-11 21:24:26
 
Started by:
Isaak Tecle
2008-06-03 15:53:50