Term id	GO:0004175
Term name	endopeptidase activity
Term definition	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
Comment

Synonyms
endoprotease activity EXACT
proteasome endopeptidase activity NARROW
proteasome endopeptidase regulator RELATED
proteinase BROAD
"endoprotease activity" EXACT []
"proteasome endopeptidase activity" NARROW []
"proteinase" BROAD []

Definition dbxrefs

Related dbxrefs
GO:0016809
Reactome:REACT_10017 "Degradation of ubiquitinated -beta catenin by the proteasome, Homo sapiens"
Reactome:REACT_101348 "Degradation of multiubiquitinated Cdh1, Rattus norvegicus"
Reactome:REACT_101866 "Ubiquitinated Cdc6 is degraded by the proteasome, Canis familiaris"
Reactome:REACT_101873 "Degradation of multiubiquitinated cell cycle proteins, Mus musculus"
Reactome:REACT_102952 "Degradation of multiubiquitinated Cdh1, Bos taurus"
Reactome:REACT_103814 "Degradation multiubiquitinated Cyclin A, Xenopus tropicalis"
Reactome:REACT_104331 "Ubiquitinated geminin is degraded by the proteasome, Mus musculus"
Reactome:REACT_104435 "Proteasome mediated degradation of Cyclin D1, Rattus norvegicus"
Reactome:REACT_104684 "Degradation of multiubiquitinated Cdh1, Danio rerio"
Reactome:REACT_104793 "Ubiquitinated Cdc6 is degraded by the proteasome, Mus musculus"
Reactome:REACT_105135 "Degradation of ubiquitinated -beta catenin by the proteasome, Canis familiaris"
Reactome:REACT_105245 "Ubiquitinated Orc1 is degraded by the proteasome, Danio rerio"
Reactome:REACT_105748 "APC/C
Reactome:REACT_106234 "Ubiquitinated Orc1 is degraded by the proteasome, Mus musculus"
Reactome:REACT_106385 "Proteasome mediated degradation of COP1, Xenopus tropicalis"
Reactome:REACT_106617 "gamma-secretase cleaves the p75NTR transmembrane domain, Bos taurus"
Reactome:REACT_106687 "SCF-mediated degradation of Emi1, Bos taurus"
Reactome:REACT_107139 "Ubiquitinated geminin is degraded by the proteasome, Canis familiaris"
Reactome:REACT_107146 "Ubiquitinated Orc1 is degraded by the proteasome, Bos taurus"
Reactome:REACT_108185 "Ubiquitinated Orc1 is degraded by the proteasome, Oryza sativa"
Reactome:REACT_108448 "Proteasome mediated degradation of PAK-2p34, Mus musculus"
Reactome:REACT_108642 "Ubiquitinated geminin is degraded by the proteasome, Xenopus tropicalis"
Reactome:REACT_109047 "Degradation of multiubiquitinated Cdh1, Oryza sativa"
Reactome:REACT_109186 "Ubiquitinated Cdc6 is degraded by the proteasome, Danio rerio"
Reactome:REACT_109261 "Degradation of multiubiquitinated cell cycle proteins, Oryza sativa"
Reactome:REACT_110165 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Danio rerio"
Reactome:REACT_110191 "26S proteosome degrades ODC holoenzyme complex, Canis familiaris"
Reactome:REACT_110448 "Proteolytic degradation of ubiquitinated-Cdc25A, Xenopus tropicalis"
Reactome:REACT_110469 "gamma-secretase cleaves the p75NTR transmembrane domain, Rattus norvegicus"
Reactome:REACT_110487 "Proteolytic degradation of ubiquitinated-Cdc25A, Danio rerio"
Reactome:REACT_110752 "gamma-secretase cleaves the p75NTR transmembrane domain, Canis familiaris"
Reactome:REACT_111098 "Processing of SCF isoform 1, Homo sapiens"
Reactome:REACT_111104 "Proteasomal cleavage of substrate, Homo sapiens"
Reactome:REACT_111172 "Proteasomal clevage of exogenous antigen, Homo sapiens"
Reactome:REACT_112076 "Ubiquitinated Cdc6 is degraded by the proteasome, Sus scrofa"
Reactome:REACT_113623 "Ubiquitinated geminin is degraded by the proteasome, Sus scrofa"
Reactome:REACT_113749 "Ubiquitinated Orc1 is degraded by the proteasome, Sus scrofa"
Reactome:REACT_114002 "Proteasome mediated degradation of PAK-2p34, Sus scrofa"
Reactome:REACT_114449 "Proteasome mediated degradation of Cyclin D1, Sus scrofa"
Reactome:REACT_114993 "Proteasome mediated degradation of COP1, Sus scrofa"
Reactome:REACT_115363 "Proteasome mediated degradation of Cyclin D1, Oryza sativa"
Reactome:REACT_115913 "Cleavage of ERBB4m80 by gamma-scretase complex, Homo sapiens"
Reactome:REACT_1210 "Ubiquitinated Cdc6 is degraded by the proteasome, Homo sapiens"
Reactome:REACT_13413 "Proteasome mediated degradation of PAK-2p34, Homo sapiens"
Reactome:REACT_13491 "26S proteosome degrades ODC holoenzyme complex, Homo sapiens"
Reactome:REACT_13505 "Proteasome mediated degradation of PAK-2p34, Homo sapiens"
Reactome:REACT_1355 "Insulin degradation, Homo sapiens"
Reactome:REACT_13609 "gamma-secretase cleaves the p75NTR transmembrane domain, Homo sapiens"
Reactome:REACT_1471 "Ubiquitinated geminin is degraded by the proteasome, Homo sapiens"
Reactome:REACT_15476 "Corticotropin cleavage from POMC, Homo sapiens"
Reactome:REACT_1673 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex, Homo sapiens"
Reactome:REACT_20637 "Proteasome mediated degradation of COP1, Homo sapiens"
Reactome:REACT_2142 "Proteasome mediated degradation of Cyclin D1, Homo sapiens"
Reactome:REACT_25343 "Destruction of AUF1 and mRNA, Homo sapiens"
Reactome:REACT_28448 "Ubiquitinated Orc1 is degraded by the proteasome, Dictyostelium discoideum"
Reactome:REACT_28452 "Proteasome mediated degradation of COP1, Bos taurus"
Reactome:REACT_28694 "Proteasome mediated degradation of Cyclin D1, Bos taurus"
Reactome:REACT_29497 "Corticotropin cleavage from POMC, Rattus norvegicus"
Reactome:REACT_29888 "Proteasome mediated degradation of COP1, Dictyostelium discoideum"
Reactome:REACT_30554 "APC/C
Reactome:REACT_31644 "Degradation of ubiquitinated -beta catenin by the proteasome, Mus musculus"
Reactome:REACT_32286 "Corticotropin cleavage from POMC, Gallus gallus"
Reactome:REACT_32345 "Proteasome mediated degradation of COP1, Rattus norvegicus"
Reactome:REACT_32454 "Corticotropin cleavage from POMC, Mus musculus"
Reactome:REACT_33103 "26S proteosome degrades ODC holoenzyme complex, Xenopus tropicalis"
Reactome:REACT_33361 "Degradation of multiubiquitinated Securin, Xenopus tropicalis"
Reactome:REACT_33702 "Proteasome mediated degradation of PAK-2p34, Drosophila melanogaster"
Reactome:REACT_34207 "Proteasome mediated degradation of PAK-2p34, Canis familiaris"
Reactome:REACT_34441 "Proteolytic degradation of ubiquitinated-Cdc25A, Rattus norvegicus"
Reactome:REACT_38775 "Ubiquitinated geminin is degraded by the proteasome, Bos taurus"
Reactome:REACT_480 "Ubiquitinated Orc1 is degraded by the proteasome, Homo sapiens"
Reactome:REACT_6715 "Degradation of multiubiquitinated Cdh1, Homo sapiens"
Reactome:REACT_6777 "Degradation of multiubiquitinated Securin, Homo sapiens"
Reactome:REACT_6826 "Degradation of multiubiquitinated cell cycle proteins, Homo sapiens"
Reactome:REACT_6878 "SCF-mediated degradation of Emi1, Homo sapiens"
Reactome:REACT_6937 "Degradation multiubiquitinated Cyclin A, Homo sapiens"
Reactome:REACT_75798 "Trimming of peptides in ER, Homo sapiens"
Reactome:REACT_75871 "Proteasomal cleavage of substrate, Homo sapiens"
Reactome:REACT_78097 "Proteasome mediated degradation of COP1, Canis familiaris"
Reactome:REACT_78726 "gamma-secretase cleaves the p75NTR transmembrane domain, Xenopus tropicalis"
Reactome:REACT_78745 "Proteasome mediated degradation of Cyclin D1, Drosophila melanogaster"
Reactome:REACT_78867 "Degradation multiubiquitinated Cyclin A, Rattus norvegicus"
Reactome:REACT_79225 "Degradation of multiubiquitinated Cdh1, Canis familiaris"
Reactome:REACT_79268 "Degradation of ubiquitinated -beta catenin by the proteasome, Drosophila melanogaster"
Reactome:REACT_79271 "Proteasome mediated degradation of Cyclin D1, Canis familiaris"
Reactome:REACT_79593 "Corticotropin cleavage from POMC, Xenopus tropicalis"
Reactome:REACT_79599 "26S proteosome degrades ODC holoenzyme complex, Danio rerio"
Reactome:REACT_79815 "gamma-secretase cleaves the p75NTR transmembrane domain, Gallus gallus"
Reactome:REACT_79882 "APC/C
Reactome:REACT_80109 "gamma-secretase cleaves the p75NTR transmembrane domain, Danio rerio"
Reactome:REACT_80331 "APC/C
Reactome:REACT_80442 "Ubiquitinated Cdc6 is degraded by the proteasome, Drosophila melanogaster"
Reactome:REACT_80463 "Degradation of multiubiquitinated Securin, Danio rerio"
Reactome:REACT_80748 "Degradation multiubiquitinated Cyclin A, Bos taurus"
Reactome:REACT_80774 "Degradation of multiubiquitinated cell cycle proteins, Rattus norvegicus"
Reactome:REACT_80978 "Proteasome mediated degradation of PAK-2p34, Xenopus tropicalis"
Reactome:REACT_81238 "Corticotropin cleavage from POMC, Bos taurus"
Reactome:REACT_81327 "SCF-mediated degradation of Emi1, Mus musculus"
Reactome:REACT_81867 "Ubiquitinated Cdc6 is degraded by the proteasome, Bos taurus"
Reactome:REACT_81958 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Canis familiaris"
Reactome:REACT_82043 "Ubiquitinated Orc1 is degraded by the proteasome, Canis familiaris"
Reactome:REACT_82474 "Ubiquitinated Cdc6 is degraded by the proteasome, Dictyostelium discoideum"
Reactome:REACT_82600 "Degradation of multiubiquitinated cell cycle proteins, Xenopus tropicalis"
Reactome:REACT_82845 "26S proteosome degrades ODC holoenzyme complex, Rattus norvegicus"
Reactome:REACT_82963 "Degradation of multiubiquitinated cell cycle proteins, Drosophila melanogaster"
Reactome:REACT_83099 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Bos taurus"
Reactome:REACT_83216 "gamma-secretase cleaves the p75NTR transmembrane domain, Sus scrofa"
Reactome:REACT_83748 "Degradation of multiubiquitinated Cdh1, Drosophila melanogaster"
Reactome:REACT_84139 "Proteasome mediated degradation of COP1, Danio rerio"
Reactome:REACT_85078 "APC/C
Reactome:REACT_86353 "Corticotropin cleavage from POMC, Danio rerio"
Reactome:REACT_86565 "SCF-mediated degradation of Emi1, Rattus norvegicus"
Reactome:REACT_873 "Proteolytic degradation of ubiquitinated-Cdc25A, Homo sapiens"
Reactome:REACT_88382 "Proteasome mediated degradation of COP1, Mus musculus"
Reactome:REACT_88509 "Proteasome mediated degradation of Cyclin D1, Mus musculus"
Reactome:REACT_88535 "Ubiquitinated Orc1 is degraded by the proteasome, Plasmodium falciparum"
Reactome:REACT_88610 "Degradation multiubiquitinated Cyclin A, Canis familiaris"
Reactome:REACT_88818 "Degradation multiubiquitinated Cyclin A, Drosophila melanogaster"
Reactome:REACT_88854 "Corticotropin cleavage from POMC, Taeniopygia guttata"
Reactome:REACT_89011 "Ubiquitinated Orc1 is degraded by the proteasome, Rattus norvegicus"
Reactome:REACT_89036 "Ubiquitinated geminin is degraded by the proteasome, Danio rerio"
Reactome:REACT_89437 "26S proteosome degrades ODC holoenzyme complex, Bos taurus"
Reactome:REACT_89505 "Corticotropin cleavage from POMC, Sus scrofa"
Reactome:REACT_89706 "Degradation of multiubiquitinated Cdh1, Xenopus tropicalis"
Reactome:REACT_90062 "SCF-mediated degradation of Emi1, Canis familiaris"
Reactome:REACT_9018 "Degradation of ubiquitinated CD4, Homo sapiens"
Reactome:REACT_9034 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Homo sapiens"
Reactome:REACT_9035 "APC/C
Reactome:REACT_90527 "SCF-mediated degradation of Emi1, Drosophila melanogaster"
Reactome:REACT_90608 "Proteasome mediated degradation of Cyclin D1, Danio rerio"
Reactome:REACT_91284 "Degradation of ubiquitinated -beta catenin by the proteasome, Bos taurus"
Reactome:REACT_91685 "Degradation of ubiquitinated -beta catenin by the proteasome, Rattus norvegicus"
Reactome:REACT_91903 "Ubiquitinated Cdc6 is degraded by the proteasome, Rattus norvegicus"
Reactome:REACT_92046 "Corticotropin cleavage from POMC, Canis familiaris"
Reactome:REACT_92221 "Ubiquitinated Cdc6 is degraded by the proteasome, Xenopus tropicalis"
Reactome:REACT_92347 "Proteasome mediated degradation of COP1, Oryza sativa"
Reactome:REACT_92586 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Xenopus tropicalis"
Reactome:REACT_92969 "Proteolytic degradation of ubiquitinated-Cdc25A, Bos taurus"
Reactome:REACT_93063 "Proteasome mediated degradation of PAK-2p34, Danio rerio"
Reactome:REACT_93174 "SCF-mediated degradation of Emi1, Xenopus tropicalis"
Reactome:REACT_93453 "Degradation of multiubiquitinated Cdh1, Mus musculus"
Reactome:REACT_93935 "gamma-secretase cleaves the p75NTR transmembrane domain, Mus musculus"
Reactome:REACT_94290 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Rattus norvegicus"
Reactome:REACT_9466 "Proteosome-mediated degradation of APOBEC3G, Homo sapiens"
Reactome:REACT_94694 "Degradation of multiubiquitinated Securin, Canis familiaris"
Reactome:REACT_95326 "Degradation of multiubiquitinated cell cycle proteins, Canis familiaris"
Reactome:REACT_95413 "Degradation of multiubiquitinated cell cycle proteins, Danio rerio"
Reactome:REACT_95513 "Proteolytic degradation of ubiquitinated-Cdc25A, Canis familiaris"
Reactome:REACT_95865 "Proteolytic degradation of ubiquitinated-Cdc25A, Mus musculus"
Reactome:REACT_96387 "Degradation multiubiquitinated Cyclin A, Mus musculus"
Reactome:REACT_96712 "Degradation of multiubiquitinated Securin, Drosophila melanogaster"
Reactome:REACT_96853 "Ubiquitinated Orc1 is degraded by the proteasome, Xenopus tropicalis"
Reactome:REACT_96908 "Ubiquitinated Orc1 is degraded by the proteasome, Drosophila melanogaster"
Reactome:REACT_97049 "Ubiquitinated Cdc6 is degraded by the proteasome, Oryza sativa"
Reactome:REACT_97235 "APC/C
Reactome:REACT_97302 "Proteasome mediated degradation of Cyclin D1, Xenopus tropicalis"
Reactome:REACT_97473 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Mus musculus"
Reactome:REACT_97709 "Degradation multiubiquitinated Cyclin A, Danio rerio"
Reactome:REACT_97826 "Degradation of multiubiquitinated cell cycle proteins, Bos taurus"
Reactome:REACT_97966 "APC/C
Reactome:REACT_98412 "APC/C
Reactome:REACT_98429 "Degradation of ubiquitinated -beta catenin by the proteasome, Xenopus tropicalis"
Reactome:REACT_98617 "Degradation of multiubiquitinated Securin, Mus musculus"
Reactome:REACT_98707 "Proteasome mediated degradation of PAK-2p34, Rattus norvegicus"
Reactome:REACT_98822 "Degradation of multiubiquitinated Securin, Rattus norvegicus"
Reactome:REACT_98901 "Degradation of multiubiquitinated Securin, Bos taurus"
Reactome:REACT_98932 "Ubiquitinated geminin is degraded by the proteasome, Rattus norvegicus"
Reactome:REACT_99506 "26S proteosome degrades ODC holoenzyme complex, Mus musculus"
Reactome:REACT_99644 "Proteolytic degradation of ubiquitinated-Cdc25A, Drosophila melanogaster"

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