Term id	GO:0004252
Term name	serine-type endopeptidase activity
Term definition	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Comment

Synonyms
blood coagulation factor activity RELATED
"blood coagulation factor activity" RELATED []

Definition dbxrefs

Related dbxrefs
EC:3.4.21
Reactome:REACT_100031 "crosslinked fibrin multimer
Reactome:REACT_100125 "Granzyme-B activates BID by cleavage, Mus musculus"
Reactome:REACT_100194 "Thrombin-mediated activation of Proteinase-activated receptors, Taeniopygia guttata"
Reactome:REACT_100271 "pro-factor IX -> factor IX + factor IX propeptide, Rattus norvegicus"
Reactome:REACT_100321 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_10058 "Part of pro-beta-NGF is processed to mature beta-NGF, Homo sapiens"
Reactome:REACT_100669 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Rattus norvegicus"
Reactome:REACT_100764 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_100842 "pro-factor VII -> factor VII + factor VII propeptide, Canis familiaris"
Reactome:REACT_100919 "Formation of alternate C5 convertase, Mus musculus"
Reactome:REACT_100938 "Proteolysis of the IGF
Reactome:REACT_101008 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_101012 "factor IX -> factor IXa + factor IX activation peptide (TF
Reactome:REACT_101033 "Processing of Proglucagon to Glucagon-like Peptide-1, Rattus norvegicus"
Reactome:REACT_101265 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Gallus gallus"
Reactome:REACT_101293 "pro-factor IX -> factor IX + factor IX propeptide, Mus musculus"
Reactome:REACT_101358 "Notch 1 precursor cleaved to form a heterodimer, Rattus norvegicus"
Reactome:REACT_101408 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Bos taurus"
Reactome:REACT_101486 "Granzyme-B activates BID by cleavage, Canis familiaris"
Reactome:REACT_101710 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Bos taurus"
Reactome:REACT_102047 "Processing of preproGLP-1 to proGLP-1, Xenopus tropicalis"
Reactome:REACT_102222 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Danio rerio"
Reactome:REACT_102226 "factor Va -> factor Vi, Taeniopygia guttata"
Reactome:REACT_102247 "urokinase plasminogen activator (one-chain)
Reactome:REACT_102300 "pro-factor VII -> factor VII + factor VII propeptide, Gallus gallus"
Reactome:REACT_102318 "Processing of preproGLP-1 to proGLP-1, Mus musculus"
Reactome:REACT_102435 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Canis familiaris"
Reactome:REACT_102450 "crosslinked fibrin multimer
Reactome:REACT_102555 "Cleavage of ATF6-alpha by S1P, Drosophila melanogaster"
Reactome:REACT_102564 "Notch 1 precursor cleaved to form a heterodimer, Mus musculus"
Reactome:REACT_102660 "Factor D cleaves C3b-bound Factor B, Danio rerio"
Reactome:REACT_102717 "factor Va -> factor Vi, Bos taurus"
Reactome:REACT_102762 "plasminogen
Reactome:REACT_103193 "thrombin
Reactome:REACT_103297 "Extracellular processing of novel PDGFs, Gallus gallus"
Reactome:REACT_103317 "protein C -> activated protein C + protein C heavy chain activation peptide, Bos taurus"
Reactome:REACT_103386 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Xenopus tropicalis"
Reactome:REACT_103434 "Processing of Proinsulin to Insulin, Rattus norvegicus"
Reactome:REACT_103529 "crosslinked fibrin multimer
Reactome:REACT_103532 "Processing of classical PDGFs, Gallus gallus"
Reactome:REACT_103534 "Latent TGF-beta1 is cleaved by furin, Xenopus tropicalis"
Reactome:REACT_103821 "pro-factor X -> factor X + factor X propeptide, Gallus gallus"
Reactome:REACT_104063 "Proteolysis of the IGF
Reactome:REACT_104096 "Processing of preproGLP-1 to proGLP-1, Canis familiaris"
Reactome:REACT_104436 "pro-factor IX -> factor IX + factor IX propeptide, Gallus gallus"
Reactome:REACT_104461 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Danio rerio"
Reactome:REACT_104513 "Conversion of C2 into C2a and C2b, Mus musculus"
Reactome:REACT_104582 "Part of pro-beta-NGF is processed to mature beta-NGF, Sus scrofa"
Reactome:REACT_104633 "factor Va -> factor Vi, Mus musculus"
Reactome:REACT_104789 "crosslinked fibrin multimer
Reactome:REACT_104808 "Processing of Proinsulin to Insulin, Taeniopygia guttata"
Reactome:REACT_104872 "Cleavage of ATF6-alpha by S1P, Gallus gallus"
Reactome:REACT_104930 "pro-factor IX -> factor IX + factor IX propeptide, Sus scrofa"
Reactome:REACT_105381 "Notch 1 precursor cleaved to form a heterodimer, Danio rerio"
Reactome:REACT_105667 "Processing of Proglucagon to Glucagon-like Peptide-1, Canis familiaris"
Reactome:REACT_105786 "Processing of Proglucagon to Glucagon-like Peptide-1, Taeniopygia guttata"
Reactome:REACT_106150 "pro-GAS6 -> GAS6 + GAS6 propeptide, Sus scrofa"
Reactome:REACT_106201 "Processing of proGIP to GIP, Rattus norvegicus"
Reactome:REACT_106288 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Rattus norvegicus"
Reactome:REACT_106360 "pro-factor IX -> factor IX + factor IX propeptide, Danio rerio"
Reactome:REACT_106442 "Cleavage of the Signal Peptide of Preproghrelin, Bos taurus"
Reactome:REACT_1065 "pro-prothrombin -> prothrombin + prothrombin propeptide, Homo sapiens"
Reactome:REACT_106545 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Canis familiaris"
Reactome:REACT_106587 "pro-prothrombin -> prothrombin + prothrombin propeptide, Mus musculus"
Reactome:REACT_106621 "Notch 3 precursor cleaved to form a heterodimer, Canis familiaris"
Reactome:REACT_106696 "C3(H2O)
Reactome:REACT_106726 "pro-GAS6 -> GAS6 + GAS6 propeptide, Taeniopygia guttata"
Reactome:REACT_106877 "plasminogen
Reactome:REACT_106997 "kallikrein
Reactome:REACT_107059 "pro-factor IX -> factor IX + factor IX propeptide, Canis familiaris"
Reactome:REACT_1071 "factor Va -> factor Vi, Homo sapiens"
Reactome:REACT_107173 "pro-protein Z -> protein Z + protein Z propeptide, Rattus norvegicus"
Reactome:REACT_107386 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Sus scrofa"
Reactome:REACT_107456 "plasminogen
Reactome:REACT_107494 "Processing of preproGLP-1 to proGLP-1, Sus scrofa"
Reactome:REACT_107597 "Granzyme-B activates BID by cleavage, Sus scrofa"
Reactome:REACT_107831 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Gallus gallus"
Reactome:REACT_107946 "pro-protein S -> protein S + protein S propeptide, Sus scrofa"
Reactome:REACT_108231 "Activation of C1R, Sus scrofa"
Reactome:REACT_108261 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Bos taurus"
Reactome:REACT_108266 "Cleavage of ATF6-alpha by S1P, Canis familiaris"
Reactome:REACT_108267 "Processing of proGIP to GIP, Canis familiaris"
Reactome:REACT_108525 "pro-factor VII -> factor VII + factor VII propeptide, Danio rerio"
Reactome:REACT_108824 "Extracellular processing of novel PDGFs, Canis familiaris"
Reactome:REACT_108968 "Proteolysis of the IGF
Reactome:REACT_109057 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Danio rerio"
Reactome:REACT_109058 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Canis familiaris"
Reactome:REACT_109495 "Notch 2 precursor cleaved to form a heterodimer, Drosophila melanogaster"
Reactome:REACT_109499 "Processing of Proglucagon to Glucagon-like Peptide-1, Sus scrofa"
Reactome:REACT_1097 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Homo sapiens"
Reactome:REACT_109879 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_109955 "Cleavage of ATF6-alpha by S1P, Taeniopygia guttata"
Reactome:REACT_110020 "Thrombin-mediated activation of Proteinase-activated receptors, Mus musculus"
Reactome:REACT_110040 "pro-factor IX -> factor IX + factor IX propeptide, Taeniopygia guttata"
Reactome:REACT_110135 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Gallus gallus"
Reactome:REACT_110160 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Taeniopygia guttata"
Reactome:REACT_110219 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Mus musculus"
Reactome:REACT_110269 "factor VII -> factor VIIa, Danio rerio"
Reactome:REACT_110434 "factor IX -> factor IXa + factor IX activation peptide (TF
Reactome:REACT_110438 "Part of pro-beta-NGF is processed to mature beta-NGF, Mus musculus"
Reactome:REACT_110522 "Notch 4 precursor cleaved to form a heterodimer, Bos taurus"
Reactome:REACT_110563 "plasminogen
Reactome:REACT_110705 "Proteolysis of the IGF
Reactome:REACT_110746 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Mus musculus"
Reactome:REACT_110798 "factor XI
Reactome:REACT_110898 "Extracellular processing of novel PDGFs, Mus musculus"
Reactome:REACT_111180 "Cleavage of Nodal Proprotein, Mus musculus"
Reactome:REACT_111228 "Cleavage of NODAL Proprotein, Homo sapiens"
Reactome:REACT_1117 "pro-GAS6 -> GAS6 + GAS6 propeptide, Homo sapiens"
Reactome:REACT_112053 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_112058 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_112131 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_11214 "The signal peptide is excised from pre-pro-NGF, Mus musculus"
Reactome:REACT_112143 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_112184 "crosslinked fibrin multimer
Reactome:REACT_112194 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_112204 "factor VIII
Reactome:REACT_112253 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Danio rerio"
Reactome:REACT_112277 "Granzyme-B activates BID by cleavage, Xenopus tropicalis"
Reactome:REACT_112440 "factor IX -> factor IXa + factor IX activation peptide (TF
Reactome:REACT_112453 "Notch 3 precursor cleaved to form a heterodimer, Drosophila melanogaster"
Reactome:REACT_112489 "factor VIII
Reactome:REACT_112510 "factor VIII
Reactome:REACT_112675 "factor VIII
Reactome:REACT_1127 "Notch 1 precursor cleaved to form a heterodimer, Homo sapiens"
Reactome:REACT_112763 "Notch 4 precursor cleaved to form a heterodimer, Xenopus tropicalis"
Reactome:REACT_112800 "Latent TGF-beta1 is cleaved by furin, Caenorhabditis elegans"
Reactome:REACT_112843 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_113002 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_113239 "factor VIII
Reactome:REACT_113539 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_113596 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_113760 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_113831 "crosslinked fibrin multimer
Reactome:REACT_114057 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Sus scrofa"
Reactome:REACT_114147 "factor VIII
Reactome:REACT_114209 "factor VIII
Reactome:REACT_114347 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Xenopus tropicalis"
Reactome:REACT_114464 "crosslinked fibrin multimer
Reactome:REACT_115043 "Latent TGF-beta1 is cleaved by furin, Drosophila melanogaster"
Reactome:REACT_115078 "factor VIII
Reactome:REACT_115086 "factor VIII
Reactome:REACT_115256 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_115338 "protein C -> activated protein C + protein C heavy chain activation peptide, Xenopus tropicalis"
Reactome:REACT_115742 "Signal peptide cleavage from ribosome-associated nascent protein, Homo sapiens"
Reactome:REACT_118086 "Signal peptide cleavage from ribosome-associated nascent protein, Oryza sativa"
Reactome:REACT_118100 "Signal peptide cleavage from ribosome-associated nascent protein, Xenopus tropicalis"
Reactome:REACT_118128 "Signal peptide cleavage from ribosome-associated nascent protein, Arabidopsis thaliana"
Reactome:REACT_118174 "Signal peptide cleavage from ribosome-associated nascent protein, Caenorhabditis elegans"
Reactome:REACT_118183 "Signal peptide cleavage from ribosome-associated nascent protein, Danio rerio"
Reactome:REACT_118198 "Signal peptide cleavage from ribosome-associated nascent protein, Drosophila melanogaster"
Reactome:REACT_118250 "Signal peptide cleavage from ribosome-associated nascent protein, Dictyostelium discoideum"
Reactome:REACT_118264 "Signal peptide cleavage from ribosome-associated nascent protein, Taeniopygia guttata"
Reactome:REACT_118287 "Signal peptide cleavage from ribosome-associated nascent protein, Gallus gallus"
Reactome:REACT_118304 "Signal peptide cleavage from ribosome-associated nascent protein, Canis familiaris"
Reactome:REACT_118357 "Signal peptide cleavage from ribosome-associated nascent protein, Plasmodium falciparum"
Reactome:REACT_118392 "Signal peptide cleavage from ribosome-associated nascent protein, Mus musculus"
Reactome:REACT_118422 "Signal peptide cleavage from ribosome-associated nascent protein, Rattus norvegicus"
Reactome:REACT_1243 "Notch 3 precursor cleaved to form a heterodimer, Homo sapiens"
Reactome:REACT_1423 "pro-factor VII -> factor VII + factor VII propeptide, Homo sapiens"
Reactome:REACT_1446 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Homo sapiens"
Reactome:REACT_1455 "factor XII -> factor XIIa, Homo sapiens"
Reactome:REACT_1456 "crosslinked fibrin multimer
Reactome:REACT_1500 "thrombin
Reactome:REACT_15308 "Proteolysis of the IGF
Reactome:REACT_1535 "pro-protein Z -> protein Z + protein Z propeptide, Homo sapiens"
Reactome:REACT_1536 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Homo sapiens"
Reactome:REACT_15373 "Proteolysis of the IGF
Reactome:REACT_15374 "Processing of Proinsulin to Insulin, Homo sapiens"
Reactome:REACT_15393 "Proteolysis of the IGF
Reactome:REACT_15465 "Proteolysis of the IGF
Reactome:REACT_158 "factor IX -> factor IXa + factor IX activation peptide (TF
Reactome:REACT_1581 "factor XI
Reactome:REACT_1610 "Granzyme-B activates BID by cleavage, Homo sapiens"
Reactome:REACT_1644 "pro-factor X -> factor X + factor X propeptide, Homo sapiens"
Reactome:REACT_1668 "factor X -> factor Xa + factor X activation peptide (VIIIa
Reactome:REACT_1676 "Notch 2 precursor cleaved to form a heterodimer, Homo sapiens"
Reactome:REACT_16891 "Extracellular processing of novel PDGFs, Homo sapiens"
Reactome:REACT_17059 "Processing of classical PDGFs, Homo sapiens"
Reactome:REACT_18401 "Cleavage of ATF6-alpha by S1P, Homo sapiens"
Reactome:REACT_1860 "pro-protein S -> protein S + protein S propeptide, Homo sapiens"
Reactome:REACT_19170 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Homo sapiens"
Reactome:REACT_19296 "Cleavage of the Signal Peptide of Preproghrelin, Homo sapiens"
Reactome:REACT_2004 "kallikrein
Reactome:REACT_2028 "crosslinked fibrin multimer
Reactome:REACT_20669 "Cleavage of the Signal Peptide of Preprolactin by Signal Peptidase (Canis), Bos taurus"
Reactome:REACT_2073 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Homo sapiens"
Reactome:REACT_2114 "Notch 4 precursor cleaved to form a heterodimer, Homo sapiens"
Reactome:REACT_214 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Homo sapiens"
Reactome:REACT_2146 "pro-protein C -> protein C + protein C propeptide, Homo sapiens"
Reactome:REACT_217 "factor VIII
Reactome:REACT_2226 "crosslinked fibrin multimer
Reactome:REACT_23836 "Processing of ProGip to Gip (mouse), Mus musculus"
Reactome:REACT_23854 "Processing of Proglucagon to Glucagon-like Peptide-1 (7-37) (mouse), Mus musculus"
Reactome:REACT_23859 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Homo sapiens"
Reactome:REACT_23880 "Processing of proGIP to GIP, Homo sapiens"
Reactome:REACT_23888 "Processing of preproGIP to proGIP, Homo sapiens"
Reactome:REACT_23895 "Processing of Proglucagon to Glucagon-like Peptide-1, Homo sapiens"
Reactome:REACT_23907 "Processing of preproGLP-1 to proGLP-1, Homo sapiens"
Reactome:REACT_23940 "Processing of Proglucagon to Glucagon-like Peptide-1 (7-36) (mouse), Mus musculus"
Reactome:REACT_23981 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Homo sapiens"
Reactome:REACT_245 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_28116 "factor XI
Reactome:REACT_28152 "pro-prothrombin -> prothrombin + prothrombin propeptide, Sus scrofa"
Reactome:REACT_28164 "Part of pro-beta-NGF is processed to mature beta-NGF, Rattus norvegicus"
Reactome:REACT_28332 "Cleavage of ATF6-alpha by S1P, Danio rerio"
Reactome:REACT_28354 "Conversion of C4 into C4a and C4b, Bos taurus"
Reactome:REACT_28382 "pro-GAS6 -> GAS6 + GAS6 propeptide, Canis familiaris"
Reactome:REACT_28391 "pro-protein C -> protein C + protein C propeptide, Taeniopygia guttata"
Reactome:REACT_28533 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_28597 "protein C -> activated protein C + protein C heavy chain activation peptide, Rattus norvegicus"
Reactome:REACT_28631 "Processing of classical PDGFs, Xenopus tropicalis"
Reactome:REACT_28673 "Notch 2 precursor cleaved to form a heterodimer, Gallus gallus"
Reactome:REACT_28723 "protein C -> activated protein C + protein C heavy chain activation peptide, Canis familiaris"
Reactome:REACT_28758 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Gallus gallus"
Reactome:REACT_28923 "Activation of C1S, Mus musculus"
Reactome:REACT_29316 "pro-factor X -> factor X + factor X propeptide, Xenopus tropicalis"
Reactome:REACT_29593 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_29596 "Extracellular processing of novel PDGFs, Taeniopygia guttata"
Reactome:REACT_29653 "kallikrein
Reactome:REACT_29792 "crosslinked fibrin multimer
Reactome:REACT_29846 "pro-factor X -> factor X + factor X propeptide, Taeniopygia guttata"
Reactome:REACT_29855 "Proteolysis of the IGF
Reactome:REACT_29954 "Activation of C1R, Xenopus tropicalis"
Reactome:REACT_30094 "factor V -> factor Va + factor V activation peptide, Taeniopygia guttata"
Reactome:REACT_30232 "Cleavage of the Signal Peptide of Preproghrelin, Mus musculus"
Reactome:REACT_30422 "Notch 4 precursor cleaved to form a heterodimer, Mus musculus"
Reactome:REACT_30489 "Processing of Proinsulin to Insulin, Danio rerio"
Reactome:REACT_30505 "Processing of proGIP to GIP, Bos taurus"
Reactome:REACT_31158 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Taeniopygia guttata"
Reactome:REACT_31164 "pro-protein S -> protein S + protein S propeptide, Mus musculus"
Reactome:REACT_31280 "Processing of Proinsulin to Insulin, Xenopus tropicalis"
Reactome:REACT_31419 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Sus scrofa"
Reactome:REACT_31420 "Part of pro-beta-NGF is processed to mature beta-NGF, Taeniopygia guttata"
Reactome:REACT_31582 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Bos taurus"
Reactome:REACT_31786 "pro-GAS6 -> GAS6 + GAS6 propeptide, Bos taurus"
Reactome:REACT_31846 "pro-protein S -> protein S + protein S propeptide, Danio rerio"
Reactome:REACT_32001 "Notch 2 precursor cleaved to form a heterodimer, Canis familiaris"
Reactome:REACT_32108 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Canis familiaris"
Reactome:REACT_32118 "factor XII -> factor XIIa, Rattus norvegicus"
Reactome:REACT_32241 "Processing of preproGLP-1 to proGLP-1, Rattus norvegicus"
Reactome:REACT_32341 "Activation of C1R, Bos taurus"
Reactome:REACT_32350 "plasminogen
Reactome:REACT_32753 "crosslinked fibrin multimer
Reactome:REACT_32785 "Processing of classical PDGFs, Sus scrofa"
Reactome:REACT_32919 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_32975 "thrombin
Reactome:REACT_32977 "Thrombin-mediated activation of Proteinase-activated receptors, Xenopus tropicalis"
Reactome:REACT_33012 "Processing of classical PDGFs, Mus musculus"
Reactome:REACT_33038 "Activation of C1S, Rattus norvegicus"
Reactome:REACT_33127 "Cleavage of C3 by C3 convertases, Sus scrofa"
Reactome:REACT_33210 "Latent TGF-beta1 is cleaved by furin, Canis familiaris"
Reactome:REACT_33288 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Rattus norvegicus"
Reactome:REACT_33326 "thrombin
Reactome:REACT_33367 "Thrombin-mediated activation of Proteinase-activated receptors, Bos taurus"
Reactome:REACT_33418 "plasminogen
Reactome:REACT_33841 "pro-protein Z -> protein Z + protein Z propeptide, Mus musculus"
Reactome:REACT_33939 "Proteolysis of the IGF
Reactome:REACT_33975 "Extracellular processing of novel PDGFs, Bos taurus"
Reactome:REACT_34064 "factor V -> factor Va + factor V activation peptide, Sus scrofa"
Reactome:REACT_34085 "factor VII -> factor VIIa, Rattus norvegicus"
Reactome:REACT_34137 "urokinase plasminogen activator (one-chain)
Reactome:REACT_34159 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Mus musculus"
Reactome:REACT_34262 "Conversion of C2 into C2a and C2b, Gallus gallus"
Reactome:REACT_34275 "Processing of Proinsulin to Insulin, Bos taurus"
Reactome:REACT_34474 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Mus musculus"
Reactome:REACT_34555 "Proteolysis of the IGF
Reactome:REACT_34558 "Processing of Proglucagon to Glucagon-like Peptide-1, Gallus gallus"
Reactome:REACT_374 "protein C -> activated protein C + protein C heavy chain activation peptide, Homo sapiens"
Reactome:REACT_37926 "Processing of preproGLP-1 to proGLP-1, Gallus gallus"
Reactome:REACT_41363 "factor VII -> factor VIIa, Canis familiaris"
Reactome:REACT_41656 "Thrombin-mediated activation of Proteinase-activated receptors, Canis familiaris"
Reactome:REACT_420 "pro-factor IX -> factor IX + factor IX propeptide, Homo sapiens"
Reactome:REACT_493 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_547 "urokinase plasminogen activator (one-chain)
Reactome:REACT_598 "plasminogen
Reactome:REACT_59890 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Gallus gallus"
Reactome:REACT_64320 "factor V -> factor Va + factor V activation peptide, Bos taurus"
Reactome:REACT_65367 "Proteolysis of the IGF
Reactome:REACT_6931 "Latent TGF-beta1 is cleaved by furin, Homo sapiens"
Reactome:REACT_708 "factor V -> factor Va + factor V activation peptide, Homo sapiens"
Reactome:REACT_72 "Thrombin-mediated activation of Proteinase-activated receptors, Homo sapiens"
Reactome:REACT_729 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin), Homo sapiens"
Reactome:REACT_739 "plasminogen
Reactome:REACT_75563 "pro-factor X -> factor X + factor X propeptide, Rattus norvegicus"
Reactome:REACT_76942 "Processing of Proinsulin to Insulin, Canis familiaris"
Reactome:REACT_76945 "Proteolysis of the IGF
Reactome:REACT_76972 "factor V -> factor Va + factor V activation peptide, Gallus gallus"
Reactome:REACT_77116 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Mus musculus"
Reactome:REACT_77208 "pro-factor X -> factor X + factor X propeptide, Mus musculus"
Reactome:REACT_77419 "factor V -> factor Va + factor V activation peptide, Mus musculus"
Reactome:REACT_77528 "Notch 3 precursor cleaved to form a heterodimer, Mus musculus"
Reactome:REACT_77756 "pro-protein C -> protein C + protein C propeptide, Xenopus tropicalis"
Reactome:REACT_77779 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Gallus gallus"
Reactome:REACT_77797 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Taeniopygia guttata"
Reactome:REACT_77805 "factor IX -> factor IXa + factor IX activation peptide (TF
Reactome:REACT_77894 "kallikrein
Reactome:REACT_77968 "Proteolysis of the IGF
Reactome:REACT_78022 "pro-factor VII -> factor VII + factor VII propeptide, Xenopus tropicalis"
Reactome:REACT_78188 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Sus scrofa"
Reactome:REACT_78229 "factor Va -> factor Vi, Rattus norvegicus"
Reactome:REACT_78374 "pro-protein C -> protein C + protein C propeptide, Rattus norvegicus"
Reactome:REACT_78406 "Thrombin-mediated activation of Proteinase-activated receptors, Danio rerio"
Reactome:REACT_78477 "crosslinked fibrin multimer
Reactome:REACT_78734 "Extracellular processing of novel PDGFs, Sus scrofa"
Reactome:REACT_78776 "crosslinked fibrin multimer
Reactome:REACT_78830 "Proteolysis of the IGF
Reactome:REACT_79061 "plasminogen
Reactome:REACT_79079 "Latent TGF-beta1 is cleaved by furin, Danio rerio"
Reactome:REACT_79192 "Activation of C1S, Sus scrofa"
Reactome:REACT_79426 "crosslinked fibrin multimer
Reactome:REACT_79431 "crosslinked fibrin multimer
Reactome:REACT_7948 "C3(H2O)
Reactome:REACT_79486 "Cleavage of C3 by C3 convertases, Canis familiaris"
Reactome:REACT_79539 "Notch 4 precursor cleaved to form a heterodimer, Canis familiaris"
Reactome:REACT_7959 "Conversion of C2 into C2a and C2b, Homo sapiens"
Reactome:REACT_79601 "urokinase plasminogen activator (one-chain)
Reactome:REACT_79616 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_79687 "Processing of classical PDGFs, Bos taurus"
Reactome:REACT_7977 "Activation of C1S, Homo sapiens"
Reactome:REACT_7978 "Activation of C1R, Homo sapiens"
Reactome:REACT_7981 "Factor D cleaves C3(H2O)-bound Factor B, Homo sapiens"
Reactome:REACT_79835 "plasminogen
Reactome:REACT_7986 "Formation of alternate C5 convertase, Homo sapiens"
Reactome:REACT_7989 "Activation of C5, Homo sapiens"
Reactome:REACT_7990 "Cleavage of C3 by C3 convertases, Homo sapiens"
Reactome:REACT_79971 "factor IX -> factor IXa + factor IX activation peptide (TF
Reactome:REACT_8002 "Conversion of C4 into C4a and C4b, Homo sapiens"
Reactome:REACT_80078 "Conversion of C4 into C4a and C4b, Mus musculus"
Reactome:REACT_80147 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Danio rerio"
Reactome:REACT_8026 "Factor D cleaves C3b-bound Factor B, Homo sapiens"
Reactome:REACT_80346 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Mus musculus"
Reactome:REACT_80454 "Processing of preproGLP-1 to proGLP-1, Danio rerio"
Reactome:REACT_80614 "Processing of classical PDGFs, Danio rerio"
Reactome:REACT_80657 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Bos taurus"
Reactome:REACT_80718 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Taeniopygia guttata"
Reactome:REACT_80779 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Bos taurus"
Reactome:REACT_80788 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Rattus norvegicus"
Reactome:REACT_80828 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Canis familiaris"
Reactome:REACT_80892 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_80961 "Cleavage of C3 by C3 convertases, Mus musculus"
Reactome:REACT_81323 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Rattus norvegicus"
Reactome:REACT_81333 "C3(H2O)
Reactome:REACT_81337 "kallikrein
Reactome:REACT_81354 "Notch 2 precursor cleaved to form a heterodimer, Rattus norvegicus"
Reactome:REACT_81372 "Part of pro-beta-NGF is processed to mature beta-NGF, Danio rerio"
Reactome:REACT_81541 "Cleavage of ATF6-alpha by S1P, Sus scrofa"
Reactome:REACT_81561 "pro-prothrombin -> prothrombin + prothrombin propeptide, Gallus gallus"
Reactome:REACT_81777 "Activation of C1R, Rattus norvegicus"
Reactome:REACT_81795 "pro-protein C -> protein C + protein C propeptide, Mus musculus"
Reactome:REACT_81849 "Conversion of C4 into C4a and C4b, Xenopus tropicalis"
Reactome:REACT_82153 "Thrombin-mediated activation of Proteinase-activated receptors, Sus scrofa"
Reactome:REACT_82158 "Notch 1 precursor cleaved to form a heterodimer, Taeniopygia guttata"
Reactome:REACT_82372 "pro-protein C -> protein C + protein C propeptide, Bos taurus"
Reactome:REACT_82390 "C3(H2O)
Reactome:REACT_82497 "Notch 3 precursor cleaved to form a heterodimer, Rattus norvegicus"
Reactome:REACT_82637 "Proteolysis of the IGF
Reactome:REACT_82647 "pro-protein Z -> protein Z + protein Z propeptide, Bos taurus"
Reactome:REACT_82729 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Xenopus tropicalis"
Reactome:REACT_82816 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Danio rerio"
Reactome:REACT_82968 "Cleavage of C3 by C3 convertases, Bos taurus"
Reactome:REACT_83445 "plasminogen
Reactome:REACT_83461 "pro-factor X -> factor X + factor X propeptide, Canis familiaris"
Reactome:REACT_83499 "urokinase plasminogen activator (one-chain)
Reactome:REACT_83770 "Proteolysis of the IGF
Reactome:REACT_83777 "C3(H2O)
Reactome:REACT_84044 "Cleavage of C3 by C3 convertases, Danio rerio"
Reactome:REACT_84046 "Activation of C5, Bos taurus"
Reactome:REACT_84129 "Processing of classical PDGFs, Rattus norvegicus"
Reactome:REACT_84217 "Processing of classical PDGFs, Canis familiaris"
Reactome:REACT_84258 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Mus musculus"
Reactome:REACT_84261 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Xenopus tropicalis"
Reactome:REACT_84305 "pro-factor X -> factor X + factor X propeptide, Sus scrofa"
Reactome:REACT_84322 "pro-protein S -> protein S + protein S propeptide, Canis familiaris"
Reactome:REACT_84434 "Activation of C5, Mus musculus"
Reactome:REACT_84524 "Factor D cleaves C3b-bound Factor B, Sus scrofa"
Reactome:REACT_84531 "factor Va -> factor Vi, Canis familiaris"
Reactome:REACT_84561 "Formation of alternate C5 convertase, Bos taurus"
Reactome:REACT_84599 "Processing of preproGIP to proGIP, Mus musculus"
Reactome:REACT_84623 "Activation of C1R, Mus musculus"
Reactome:REACT_84646 "factor V -> factor Va + factor V activation peptide, Xenopus tropicalis"
Reactome:REACT_84664 "Latent TGF-beta1 is cleaved by furin, Mus musculus"
Reactome:REACT_84693 "crosslinked fibrin multimer
Reactome:REACT_84795 "Conversion of C4 into C4a and C4b, Sus scrofa"
Reactome:REACT_84822 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Sus scrofa"
Reactome:REACT_85002 "Proteolysis of the IGF
Reactome:REACT_85145 "factor VII -> factor VIIa, Xenopus tropicalis"
Reactome:REACT_85207 "pro-protein S -> protein S + protein S propeptide, Taeniopygia guttata"
Reactome:REACT_85433 "factor XI
Reactome:REACT_85582 "Processing of Proinsulin to Insulin, Mus musculus"
Reactome:REACT_85635 "crosslinked fibrin multimer
Reactome:REACT_85732 "pro-protein S -> protein S + protein S propeptide, Bos taurus"
Reactome:REACT_85824 "Proteolysis of the IGF
Reactome:REACT_85897 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Gallus gallus"
Reactome:REACT_85916 "pro-protein C -> protein C + protein C propeptide, Danio rerio"
Reactome:REACT_86048 "factor XI
Reactome:REACT_86053 "pro-factor VII -> factor VII + factor VII propeptide, Mus musculus"
Reactome:REACT_86117 "Granzyme-B activates BID by cleavage, Rattus norvegicus"
Reactome:REACT_86243 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Mus musculus"
Reactome:REACT_86385 "Notch 1 precursor cleaved to form a heterodimer, Xenopus tropicalis"
Reactome:REACT_86440 "Notch 2 precursor cleaved to form a heterodimer, Sus scrofa"
Reactome:REACT_86442 "Notch 3 precursor cleaved to form a heterodimer, Xenopus tropicalis"
Reactome:REACT_86459 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Xenopus tropicalis"
Reactome:REACT_86497 "Activation of C1S, Bos taurus"
Reactome:REACT_86530 "urokinase plasminogen activator (one-chain)
Reactome:REACT_86627 "crosslinked fibrin multimer
Reactome:REACT_86670 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Bos taurus"
Reactome:REACT_86747 "pro-factor IX -> factor IX + factor IX propeptide, Bos taurus"
Reactome:REACT_86842 "Notch 3 precursor cleaved to form a heterodimer, Danio rerio"
Reactome:REACT_86885 "kallikrein
Reactome:REACT_86898 "factor VII -> factor VIIa, Bos taurus"
Reactome:REACT_86969 "factor XII -> factor XIIa, Mus musculus"
Reactome:REACT_87075 "pro-factor VII -> factor VII + factor VII propeptide, Rattus norvegicus"
Reactome:REACT_87266 "Processing of Proglucagon to Glucagon-like Peptide-1, Danio rerio"
Reactome:REACT_87452 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Canis familiaris"
Reactome:REACT_87454 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_87599 "pro-prothrombin -> prothrombin + prothrombin propeptide, Xenopus tropicalis"
Reactome:REACT_87700 "factor IX -> factor IXa + factor IX activation peptide (TF
Reactome:REACT_87792 "Activation of C5, Sus scrofa"
Reactome:REACT_87800 "Notch 2 precursor cleaved to form a heterodimer, Xenopus tropicalis"
Reactome:REACT_87920 "Cleavage of ATF6-alpha by S1P, Rattus norvegicus"
Reactome:REACT_88355 "Activation of C5, Danio rerio"
Reactome:REACT_88360 "Extracellular processing of novel PDGFs, Danio rerio"
Reactome:REACT_88496 "Notch 2 precursor cleaved to form a heterodimer, Mus musculus"
Reactome:REACT_88788 "Notch 2 precursor cleaved to form a heterodimer, Danio rerio"
Reactome:REACT_88823 "Part of pro-beta-NGF is processed to mature beta-NGF, Gallus gallus"
Reactome:REACT_88980 "Conversion of C4 into C4a and C4b, Canis familiaris"
Reactome:REACT_89126 "Proteolysis of the IGF
Reactome:REACT_89188 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Rattus norvegicus"
Reactome:REACT_89330 "pro-GAS6 -> GAS6 + GAS6 propeptide, Gallus gallus"
Reactome:REACT_89358 "Proteolysis of the IGF
Reactome:REACT_89476 "Proteolysis of the IGF
Reactome:REACT_89486 "Cleavage of the Signal Peptide of Preproghrelin, Sus scrofa"
Reactome:REACT_89678 "thrombin
Reactome:REACT_89776 "kallikrein
Reactome:REACT_89824 "crosslinked fibrin multimer
Reactome:REACT_89888 "thrombin
Reactome:REACT_89976 "factor XI
Reactome:REACT_9 "factor VII -> factor VIIa, Homo sapiens"
Reactome:REACT_90020 "Notch 1 precursor cleaved to form a heterodimer, Gallus gallus"
Reactome:REACT_90057 "Activation of C5, Canis familiaris"
Reactome:REACT_90119 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_90443 "Thrombin-mediated activation of Proteinase-activated receptors, Gallus gallus"
Reactome:REACT_905 "factor XI
Reactome:REACT_90541 "pro-prothrombin -> prothrombin + prothrombin propeptide, Canis familiaris"
Reactome:REACT_90557 "plasminogen
Reactome:REACT_90602 "Notch 1 precursor cleaved to form a heterodimer, Bos taurus"
Reactome:REACT_90751 "crosslinked fibrin multimer
Reactome:REACT_90855 "Latent TGF-beta1 is cleaved by furin, Sus scrofa"
Reactome:REACT_90888 "Processing of Proglucagon to Glucagon-like Peptide-1, Bos taurus"
Reactome:REACT_90902 "crosslinked fibrin multimer
Reactome:REACT_90939 "pro-factor X -> factor X + factor X propeptide, Danio rerio"
Reactome:REACT_91056 "Factor D cleaves C3(H2O)-bound Factor B, Mus musculus"
Reactome:REACT_91167 "Part of pro-beta-NGF is processed to mature beta-NGF, Xenopus tropicalis"
Reactome:REACT_91387 "Extracellular processing of novel PDGFs, Xenopus tropicalis"
Reactome:REACT_91461 "Factor D cleaves C3(H2O)-bound Factor B, Danio rerio"
Reactome:REACT_91543 "Cleavage of the Signal Peptide of Preproghrelin, Canis familiaris"
Reactome:REACT_91726 "factor XI
Reactome:REACT_91877 "thrombin
Reactome:REACT_92031 "factor V -> factor Va + factor V activation peptide, Danio rerio"
Reactome:REACT_92103 "Latent TGF-beta1 is cleaved by furin, Rattus norvegicus"
Reactome:REACT_92110 "plasminogen
Reactome:REACT_92215 "Cleavage of the Signal Peptide of Preproghrelin, Gallus gallus"
Reactome:REACT_92228 "pro-protein S -> protein S + protein S propeptide, Gallus gallus"
Reactome:REACT_92253 "factor V -> factor Va + factor V activation peptide, Rattus norvegicus"
Reactome:REACT_92261 "Notch 4 precursor cleaved to form a heterodimer, Sus scrofa"
Reactome:REACT_92422 "pro-protein S -> protein S + protein S propeptide, Xenopus tropicalis"
Reactome:REACT_92693 "Latent TGF-beta1 is cleaved by furin, Bos taurus"
Reactome:REACT_92748 "thrombin
Reactome:REACT_92823 "Notch 1 precursor cleaved to form a heterodimer, Canis familiaris"
Reactome:REACT_92949 "Proteolysis of the IGF
Reactome:REACT_93064 "crosslinked fibrin multimer
Reactome:REACT_93142 "pro-factor X -> factor X + factor X propeptide, Bos taurus"
Reactome:REACT_93274 "Processing of Proinsulin to Insulin, Gallus gallus"
Reactome:REACT_93405 "factor VII -> factor VIIa, Mus musculus"
Reactome:REACT_93445 "factor XII -> factor XIIa, Canis familiaris"
Reactome:REACT_93463 "Notch 1 precursor cleaved to form a heterodimer, Drosophila melanogaster"
Reactome:REACT_93480 "factor Va -> factor Vi, Danio rerio"
Reactome:REACT_93511 "factor XI
Reactome:REACT_93561 "crosslinked fibrin multimer
Reactome:REACT_93736 "pro-GAS6 -> GAS6 + GAS6 propeptide, Rattus norvegicus"
Reactome:REACT_94000 "Proteolysis of the IGF
Reactome:REACT_94036 "factor VII -> factor VIIa, Gallus gallus"
Reactome:REACT_94312 "pro-protein Z -> protein Z + protein Z propeptide, Gallus gallus"
Reactome:REACT_94368 "crosslinked fibrin multimer
Reactome:REACT_94599 "crosslinked fibrin multimer
Reactome:REACT_94754 "factor V -> factor Va + factor V activation peptide, Canis familiaris"
Reactome:REACT_94901 "Processing of preproGIP to proGIP, Canis familiaris"
Reactome:REACT_94902 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Rattus norvegicus"
Reactome:REACT_94933 "Part of pro-beta-NGF is processed to mature beta-NGF, Canis familiaris"
Reactome:REACT_94955 "Cleavage of ATF6-alpha by S1P, Xenopus tropicalis"
Reactome:REACT_94965 "Formation of alternate C5 convertase, Sus scrofa"
Reactome:REACT_95107 "Thrombin-mediated activation of Proteinase-activated receptors, Rattus norvegicus"
Reactome:REACT_95139 "factor IX -> factor IXa + factor IX activation peptide (TF
Reactome:REACT_95191 "pro-protein Z -> protein Z + protein Z propeptide, Xenopus tropicalis"
Reactome:REACT_95211 "factor X -> factor Xa + factor X activation peptide (TF
Reactome:REACT_95236 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Taeniopygia guttata"
Reactome:REACT_95276 "pro-prothrombin -> prothrombin + prothrombin propeptide, Taeniopygia guttata"
Reactome:REACT_95431 "factor XI
Reactome:REACT_95949 "plasminogen
Reactome:REACT_95979 "pro-GAS6 -> GAS6 + GAS6 propeptide, Mus musculus"
Reactome:REACT_96137 "crosslinked fibrin multimer
Reactome:REACT_96193 "thrombin
Reactome:REACT_96270 "pro-factor IX -> factor IX + factor IX propeptide, Xenopus tropicalis"
Reactome:REACT_96343 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Rattus norvegicus"
Reactome:REACT_96382 "Factor D cleaves C3b-bound Factor B, Mus musculus"
Reactome:REACT_96526 "C3(H2O)
Reactome:REACT_97100 "pro-protein Z -> protein Z + protein Z propeptide, Danio rerio"
Reactome:REACT_97110 "factor Va -> factor Vi, Xenopus tropicalis"
Reactome:REACT_97353 "factor XII -> factor XIIa, Bos taurus"
Reactome:REACT_97421 "pro-protein C -> protein C + protein C propeptide, Canis familiaris"
Reactome:REACT_97432 "Part of pro-beta-NGF is processed to mature beta-NGF, Bos taurus"
Reactome:REACT_97564 "crosslinked fibrin multimer
Reactome:REACT_97673 "pro-factor VII -> factor VII + factor VII propeptide, Bos taurus"
Reactome:REACT_97699 "pro-GAS6 -> GAS6 + GAS6 propeptide, Xenopus tropicalis"
Reactome:REACT_97708 "Cleavage of ATF6-alpha by S1P, Bos taurus"
Reactome:REACT_97710 "Cleavage of ATF6-alpha by S1P, Mus musculus"
Reactome:REACT_97801 "crosslinked fibrin multimer
Reactome:REACT_97855 "urokinase plasminogen activator (one-chain)
Reactome:REACT_98063 "Proteolysis of the IGF
Reactome:REACT_98097 "Activation of C1S, Xenopus tropicalis"
Reactome:REACT_98147 "Proteolysis of the IGF
Reactome:REACT_98165 "thrombin
Reactome:REACT_98203 "pro-GAS6 -> GAS6 + GAS6 propeptide, Danio rerio"
Reactome:REACT_98267 "pro-prothrombin -> prothrombin + prothrombin propeptide, Rattus norvegicus"
Reactome:REACT_98357 "pro-prothrombin -> prothrombin + prothrombin propeptide, Danio rerio"
Reactome:REACT_98392 "Extracellular processing of novel PDGFs, Rattus norvegicus"
Reactome:REACT_98494 "Processing of preproGLP-1 to proGLP-1, Taeniopygia guttata"
Reactome:REACT_98565 "Processing of preproGIP to proGIP, Rattus norvegicus"
Reactome:REACT_98659 "Factor D cleaves C3(H2O)-bound Factor B, Sus scrofa"
Reactome:REACT_98696 "pro-prothrombin -> prothrombin + prothrombin propeptide, Bos taurus"
Reactome:REACT_98749 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Bos taurus"
Reactome:REACT_98786 "Notch 3 precursor cleaved to form a heterodimer, Bos taurus"
Reactome:REACT_98917 "Formation of alternate C5 convertase, Canis familiaris"
Reactome:REACT_99191 "Proteolysis of the IGF
Reactome:REACT_99384 "Processing of classical PDGFs, Taeniopygia guttata"
Reactome:REACT_99395 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Canis familiaris"
Reactome:REACT_99405 "Notch 4 precursor cleaved to form a heterodimer, Rattus norvegicus"
Reactome:REACT_99429 "Processing of Proglucagon to Glucagon-like Peptide-1, Xenopus tropicalis"
Reactome:REACT_99443 "Cleavage of the Signal Peptide of Preproghrelin, Rattus norvegicus"
Reactome:REACT_99555 "pro-protein Z -> protein Z + protein Z propeptide, Taeniopygia guttata"
Reactome:REACT_99585 "crosslinked fibrin multimer
Reactome:REACT_99900 "protein C -> activated protein C + protein C heavy chain activation peptide, Mus musculus"
Reactome:REACT_99921 "Granzyme-B activates BID by cleavage, Bos taurus"
Reactome:REACT_99987 "Notch 2 precursor cleaved to form a heterodimer, Bos taurus"

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