Term id	GO:0004467
Term name	long-chain fatty acid-CoA ligase activity
Term definition	Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
Comment

Synonyms
ACS3 NARROW EC:6.2.1.3
acyl-activating enzyme activity BROAD EC:6.2.1.3
acyl-CoA synthetase activity EXACT EC:6.2.1.3
arachidonyl-CoA synthetase NARROW EC:6.2.1.3
FAA1 NARROW EC:6.2.1.3
fatty acid thiokinase (long chain) activity EXACT EC:6.2.1.3
fatty acid thiokinase (long-chain) activity EXACT EC:6.2.1.3
LCFA synthetase activity EXACT EC:6.2.1.3
lignoceroyl-CoA synthase activity EXACT EC:6.2.1.3
long chain fatty acyl-CoA synthetase activity EXACT EC:6.2.1.3
long-chain acyl CoA synthetase activity EXACT EC:6.2.1.3
long-chain acyl-CoA synthetase activity EXACT
long-chain acyl-CoA synthetase I NARROW EC:6.2.1.3
long-chain acyl-CoA synthetase II NARROW EC:6.2.1.3
long-chain acyl-coenzyme A synthetase activity EXACT EC:6.2.1.3
long-chain fatty acid activation RELATED
long-chain fatty acid-CoA ligase activity EXACT
long-chain fatty acyl coenzyme A synthetase activity EXACT EC:6.2.1.3
long-chain-fatty-acyl-CoA synthetase activity EXACT
oleoyl-CoA synthetase NARROW EC:6.2.1.3
palmitoyl coenzyme A synthetase NARROW EC:6.2.1.3
palmitoyl-CoA ligase NARROW EC:6.2.1.3
palmitoyl-CoA synthase NARROW EC:6.2.1.3
pristanoyl-CoA synthetase NARROW EC:6.2.1.3
stearoyl-CoA synthetase NARROW EC:6.2.1.3
thiokinase RELATED EC:6.2.1.3
"ACS3" NARROW [EC:6.2.1.3]
"acyl-activating enzyme activity" BROAD [EC:6.2.1.3]
"acyl-CoA synthetase activity" EXACT [EC:6.2.1.3]
"arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3]
"FAA1" NARROW [EC:6.2.1.3]
"fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3]
"fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3]
"LCFA synthetase activity" EXACT [EC:6.2.1.3]
"lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3]
"long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3]
"long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3]
"long-chain acyl-CoA synthetase activity" EXACT []
"long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3]
"long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3]
"long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
"long-chain fatty acid activation" RELATED []
"long-chain fatty acid-CoA ligase activity" EXACT []
"long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
"long-chain-fatty-acid-CoA ligase activity" EXACT []
"long-chain-fatty-acyl-CoA synthetase activity" EXACT []
"oleoyl-CoA synthetase" NARROW [EC:6.2.1.3]
"palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3]
"palmitoyl-CoA ligase" NARROW [EC:6.2.1.3]
"palmitoyl-CoA synthase" NARROW [EC:6.2.1.3]
"pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3]
"stearoyl-CoA synthetase" NARROW [EC:6.2.1.3]
"thiokinase" RELATED [EC:6.2.1.3]

Definition dbxrefs

Related dbxrefs
MetaCyc:ACYLCOASYN-RXN
MetaCyc:PWY-5143
Reactome:REACT_10000 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
Reactome:REACT_100146 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
Reactome:REACT_10020 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
Reactome:REACT_10034 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
Reactome:REACT_100377 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
Reactome:REACT_10049 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens"
Reactome:REACT_10064 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
Reactome:REACT_10087 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens"
Reactome:REACT_10106 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens"
Reactome:REACT_10119 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens"
Reactome:REACT_101550 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
Reactome:REACT_102048 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Bos taurus"
Reactome:REACT_102674 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio"
Reactome:REACT_102719 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
Reactome:REACT_102779 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Gallus gallus"
Reactome:REACT_103147 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Canis familiaris"
Reactome:REACT_103154 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris"
Reactome:REACT_103348 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
Reactome:REACT_104228 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
Reactome:REACT_104748 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis"
Reactome:REACT_105072 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Taeniopygia guttata"
Reactome:REACT_105167 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
Reactome:REACT_105842 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Gallus gallus"
Reactome:REACT_106315 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
Reactome:REACT_106400 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis"
Reactome:REACT_106582 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus"
Reactome:REACT_107010 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus"
Reactome:REACT_107065 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus"
Reactome:REACT_107825 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
Reactome:REACT_108040 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Drosophila melanogaster"
Reactome:REACT_108152 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus"
Reactome:REACT_108327 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus"
Reactome:REACT_108413 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Arabidopsis thaliana"
Reactome:REACT_109181 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
Reactome:REACT_109281 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Oryza sativa"
Reactome:REACT_109377 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
Reactome:REACT_109580 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Taeniopygia guttata"
Reactome:REACT_110284 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
Reactome:REACT_110400 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis"
Reactome:REACT_110600 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
Reactome:REACT_110635 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus"
Reactome:REACT_11137 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Homo sapiens"
Reactome:REACT_112002 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
Reactome:REACT_112185 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Dictyostelium discoideum"
Reactome:REACT_112197 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Mycobacterium tuberculosis"
Reactome:REACT_112234 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Dictyostelium discoideum"
Reactome:REACT_112314 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata"
Reactome:REACT_112696 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
Reactome:REACT_113165 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae"
Reactome:REACT_113283 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae"
Reactome:REACT_113402 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata"
Reactome:REACT_113433 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Plasmodium falciparum"
Reactome:REACT_113477 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
Reactome:REACT_113562 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
Reactome:REACT_113604 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata"
Reactome:REACT_114408 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae"
Reactome:REACT_114641 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae"
Reactome:REACT_114941 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae"
Reactome:REACT_115449 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata"
Reactome:REACT_115464 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Xenopus tropicalis"
Reactome:REACT_22247 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6], Homo sapiens"
Reactome:REACT_22376 "arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4], Homo sapiens"
Reactome:REACT_22410 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Homo sapiens"
Reactome:REACT_28244 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio"
Reactome:REACT_28477 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus"
Reactome:REACT_28700 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus"
Reactome:REACT_29173 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
Reactome:REACT_30197 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
Reactome:REACT_30265 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis"
Reactome:REACT_32832 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis"
Reactome:REACT_33155 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Sus scrofa"
Reactome:REACT_33243 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
Reactome:REACT_34606 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Xenopus tropicalis"
Reactome:REACT_34728 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Gallus gallus"
Reactome:REACT_77878 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Mus musculus"
Reactome:REACT_78613 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio"
Reactome:REACT_79153 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
Reactome:REACT_79206 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus"
Reactome:REACT_79554 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Danio rerio"
Reactome:REACT_79937 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Bos taurus"
Reactome:REACT_80135 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris"
Reactome:REACT_80410 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Sus scrofa"
Reactome:REACT_80584 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
Reactome:REACT_82148 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
Reactome:REACT_82230 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Saccharomyces cerevisiae"
Reactome:REACT_82547 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Xenopus tropicalis"
Reactome:REACT_83689 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Rattus norvegicus"
Reactome:REACT_83959 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Caenorhabditis elegans"
Reactome:REACT_84131 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Canis familiaris"
Reactome:REACT_84943 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus"
Reactome:REACT_85114 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
Reactome:REACT_85507 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus"
Reactome:REACT_86419 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
Reactome:REACT_86526 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
Reactome:REACT_86586 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
Reactome:REACT_86823 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Taeniopygia guttata"
Reactome:REACT_86910 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
Reactome:REACT_87364 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
Reactome:REACT_87672 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Schizosaccharomyces pombe"
Reactome:REACT_87771 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
Reactome:REACT_88190 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
Reactome:REACT_88276 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus"
Reactome:REACT_88286 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa"
Reactome:REACT_88806 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Danio rerio"
Reactome:REACT_89212 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus"
Reactome:REACT_89373 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus"
Reactome:REACT_89406 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
Reactome:REACT_89639 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis"
Reactome:REACT_89817 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Rattus norvegicus"
Reactome:REACT_89907 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
Reactome:REACT_89914 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata"
Reactome:REACT_90120 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
Reactome:REACT_90313 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa"
Reactome:REACT_91245 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris"
Reactome:REACT_91297 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Mus musculus"
Reactome:REACT_91342 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris"
Reactome:REACT_91481 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
Reactome:REACT_92094 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus"
Reactome:REACT_92380 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Caenorhabditis elegans"
Reactome:REACT_930 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Homo sapiens"
Reactome:REACT_94093 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Mus musculus"
Reactome:REACT_94281 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Rattus norvegicus"
Reactome:REACT_95456 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis"
Reactome:REACT_96062 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa"
Reactome:REACT_96718 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis"
Reactome:REACT_97075 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa"
Reactome:REACT_97472 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Canis familiaris"
Reactome:REACT_97742 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Sus scrofa"
Reactome:REACT_97937 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus"
Reactome:REACT_98426 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
Reactome:REACT_98486 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Bos taurus"
Reactome:REACT_98598 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio"
Reactome:REACT_98628 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio"
Reactome:REACT_98739 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Danio rerio"
Reactome:REACT_98845 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis"
Reactome:REACT_99260 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris"
Reactome:REACT_9970 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens"
UM-BBD_enzymeID:e0025

solQTL is running ..... 
                Please wait ..... 
                       This may take 
                            a few minutes.