Term id	GO:0004721
Term name	phosphoprotein phosphatase activity
Term definition	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
Comment

Synonyms
phosphoprotein phosphohydrolase activity EXACT EC:3.1.3.16
protein phosphatase activity EXACT
protein phosphatase-1 activity NARROW EC:3.1.3.16
protein phosphatase-2A activity NARROW EC:3.1.3.16
protein phosphatase-2B activity NARROW EC:3.1.3.16
protein phosphatase-2C activity NARROW EC:3.1.3.16
"phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16]
"protein phosphatase activity" EXACT []
"protein phosphatase-1 activity" NARROW [EC:3.1.3.16]
"protein phosphatase-2A activity" NARROW [EC:3.1.3.16]
"protein phosphatase-2B activity" NARROW [EC:3.1.3.16]
"protein phosphatase-2C activity" NARROW [EC:3.1.3.16]

Definition dbxrefs

Related dbxrefs
MetaCyc:3.1.3.16-RXN
Reactome:REACT_100556 "Dephosphorylation of Cyclin E
Reactome:REACT_101161 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_101258 "Dephosphorylation of phospho-Cdh1, Taeniopygia guttata"
Reactome:REACT_101308 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_101537 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_102055 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_102521 "Cdc25A mediated dephosphorylation of Cyclin A
Reactome:REACT_103107 "Dephosphorylation of Cyclin E
Reactome:REACT_105948 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Rattus norvegicus"
Reactome:REACT_106256 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Xenopus tropicalis"
Reactome:REACT_107500 "Dephosphorylation of cyclin B2
Reactome:REACT_107570 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_108174 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Gallus gallus"
Reactome:REACT_109144 "Cdc25A mediated dephosphorylation of Cyclin A
Reactome:REACT_109225 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_109310 "Dephosphorylation of cyclin B2
Reactome:REACT_109345 "Dephosphorylation of Cyclin E
Reactome:REACT_109732 "Cdc25A mediated dephosphorylation of Cyclin A
Reactome:REACT_110596 "Dephosphorylation of cyclin B2
Reactome:REACT_111148 "Dephosphorylation of p107 (RBL1) by PP2A, Homo sapiens"
Reactome:REACT_111170 "Dephosphorylation of p130 (RBL2) by PP2A, Homo sapiens"
Reactome:REACT_112020 "Dephosphorylation of Cyclin E
Reactome:REACT_112348 "Dephosphorylation of cyclin B2
Reactome:REACT_112617 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_112795 "Dephosphorylation of Cyclin E
Reactome:REACT_112811 "Pp2a mediated localization of Rb protein in chromatin, Xenopus tropicalis"
Reactome:REACT_112981 "Dephosphorylation of cyclin B2
Reactome:REACT_113855 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_114200 "Dephosphorylation of Cyclin E
Reactome:REACT_114550 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_115084 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_1251 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens"
Reactome:REACT_28268 "Dephosphorylation of phospho-Cdh1, Xenopus tropicalis"
Reactome:REACT_28473 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_28474 "Pp2a mediated localization of Rb protein in chromatin, Canis familiaris"
Reactome:REACT_28606 "Dephosphorylation of cyclin B2
Reactome:REACT_29645 "Dephosphorylation of cyclin B2
Reactome:REACT_30225 "Dephosphorylation of Cyclin E
Reactome:REACT_33423 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Drosophila melanogaster"
Reactome:REACT_421 "Pp2a mediated localization of Rb protein in chromatin, Homo sapiens"
Reactome:REACT_592 "Dephosphorylation of Cyclin E
Reactome:REACT_59811 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_6175 "Dephosphorylation of cyclin B2
Reactome:REACT_6206 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens"
Reactome:REACT_6255 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_6257 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_6294 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_6910 "Dephosphorylation of phospho-Cdh1, Homo sapiens"
Reactome:REACT_77578 "Dephosphorylation of phospho-Cdh1, Rattus norvegicus"
Reactome:REACT_77594 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Caenorhabditis elegans"
Reactome:REACT_77793 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_78412 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Mus musculus"
Reactome:REACT_78414 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Saccharomyces cerevisiae"
Reactome:REACT_80229 "Dephosphorylation of phospho-Cdh1, Bos taurus"
Reactome:REACT_80518 "Dephosphorylation of Cyclin E
Reactome:REACT_81016 "Dephosphorylation of phospho-Cdh1, Sus scrofa"
Reactome:REACT_81195 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_81980 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_83073 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_83503 "Dephosphorylation of cyclin B2
Reactome:REACT_83605 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Dictyostelium discoideum"
Reactome:REACT_83812 "Dephosphorylation of cyclin B2
Reactome:REACT_83951 "Dephosphorylation of cyclin B2
Reactome:REACT_84291 "Pp2a mediated localization of Rb protein in chromatin, Mus musculus"
Reactome:REACT_84834 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Danio rerio"
Reactome:REACT_84882 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_86262 "Dephosphorylation of phospho-Cdh1, Schizosaccharomyces pombe"
Reactome:REACT_86293 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Arabidopsis thaliana"
Reactome:REACT_86738 "Cdc25A mediated dephosphorylation of Cyclin A
Reactome:REACT_89601 "Dephosphorylation of phospho-Cdh1, Gallus gallus"
Reactome:REACT_89607 "Dephosphorylation of cyclin B2
Reactome:REACT_9062 "Cdc25A mediated dephosphorylation of Cyclin A
Reactome:REACT_90978 "Pp2a mediated localization of Rb protein in chromatin, Taeniopygia guttata"
Reactome:REACT_91918 "Cdc25A mediated dephosphorylation of Cyclin A
Reactome:REACT_91996 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_92154 "Dephosphorylation of phospho-Cdh1, Canis familiaris"
Reactome:REACT_92312 "Cdc25A mediated dephosphorylation of Cyclin A
Reactome:REACT_92765 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Oryza sativa"
Reactome:REACT_93167 "Cdc25A mediated dephosphorylation of Cyclin A
Reactome:REACT_93324 "Pp2a mediated localization of Rb protein in chromatin, Dictyostelium discoideum"
Reactome:REACT_94004 "Dephosphorylation of phospho-Cdh1, Danio rerio"
Reactome:REACT_95049 "Dephosphorylation of phospho-Cdh1, Mus musculus"
Reactome:REACT_95090 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_95688 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_95930 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_95992 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_97239 "Dephosphorylation of nuclear Cyclin B1
Reactome:REACT_97616 "Dephosphorylation of nuclear Cyclin A
Reactome:REACT_98140 "Dephosphorylation of Cyclin E
Reactome:REACT_98946 "Dephosphorylation of phospho-Cdh1, Saccharomyces cerevisiae"
Reactome:REACT_98958 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_98967 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Schizosaccharomyces pombe"
Reactome:REACT_99508 "Dephosphorylation of cytoplasmic Cyclin B1
Reactome:REACT_99511 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Taeniopygia guttata"
Reactome:REACT_99512 "Dephosphorylation of nuclear Cyclin B1

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