Term id	GO:0006915
Term name	apoptotic process
Term definition	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Comment

Synonyms
apoptotic cell death EXACT GOC:sl
apoptotic program NARROW GOC:add
apoptotic programmed cell death EXACT
programmed cell death by apoptosis EXACT
signaling (initiator) caspase activity RELATED
type I programmed cell death NARROW
"apoptotic cell death" EXACT [GOC:sl]
"apoptotic program" NARROW [GOC:add]
"apoptotic programmed cell death" EXACT []
"programmed cell death by apoptosis" EXACT []
"signaling (initiator) caspase activity" RELATED []
"type I programmed cell death" NARROW []
"apoptosis" NARROW []
"cell suicide" BROAD []
"cellular suicide" BROAD []
activation of apoptosis
apoptosis
apoptosis activator activity
apoptosis signaling
apoptotic cell death
apoptotic program
apoptotic programmed cell death
caspase-dependent programmed cell death
cell suicide
cellular suicide
commitment to apoptosis
induction of apoptosis
induction of apoptosis by p53
programmed cell death by apoptosis
signaling (initiator) caspase activity
type I programmed cell death

Definition dbxrefs

Related dbxrefs
GO:0006917
GO:0008632
Wikipedia:Apoptosis

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