Human-derived E-cadherin is encoded by the CDH1 gene and is currently the most studied member of the cadherin family. Its extracellular domain contains five cadherin repeats (EC1-EC5), one transmembrane domain, and one intracellular domain. Van et al found that the intracellular domain of E-cadherin contains a hyperphosphorylated region that is closely related to the binding of β-catenin, which in turn affects the function of E-cadherin.

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