Conserved Ortholog Set (COS) markers
We have used a computational method to screen the
tomato EST database against the arabidopsis genome
sequence in order to find a set of highly conserved,
single copy genes which can be used as markers for
comparative mapping between the tomato and arabidopsis
genomes. Currently we have identified approximately 1000
of these Conserved Ortholog Set (COS) markers.
In this section of SGN, you will find sequence and
clone information for each of these COS markers as well
as their matching counterpart in the arabidopsis genome.
We have surveyed these COS markers and mapped some of
these COS markers on the tomato genome to provide a
tomato: arabidopsis comparative map. This mapping
information is available on SGN now.
Because these COS markers are so highly conserved, they may also be useful for comparative mapping in other dicot species. The computational screen by how COS markers were identified is described below:
Functional annotation of COS markers
COS-markers were functionally annotated using the MIPS
role categories as they were defined at the time of the
analysis. As the functional role descriptions are subject
to continued changes, a copy of the role categories and
the COS-marker annotations as used in the analysis can be
The list of COS markers is available in both online and plain text format
Note: for the tomato map position in the table linked above: